Evidence map›Paper›PMID 36286551›Full record

ArticlemBio2022

The Vi Capsular Polysaccharide of Salmonella Typhi Promotes Macrophage Phagocytosis by Binding the Human C-Type Lectin DC-SIGN.

Lillian F Zhang, Bernd Lepenies, Sayuri Nakamae, Briana M Young, Renato L Santos, Manuela Raffatellu, Brian A Cobb, Hirotaka Hiyoshi, Andreas J Bäumler

Open access · goldAbstract read
In one paragraph

Article in mBio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 23 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Microorganisms · 2026
    Review
  5. Genomic and antimicrobial susceptibility characterization of a clinicalFrontiers in cellular and infection microbiology · 2026
    Article
  6. Article
  7. Infection biology ofEcoSal Plus · 2024
    Review
  8. Article
  9. medRxiv : the preprint server for health sciences · 2024
    Article
  10. Article
  11. Article
  12. Review
  13. Aptamers: precision tools for diagnosing and treating infectious diseases.Frontiers in cellular and infection microbiology · 2024
    Review
  14. Frontiers in cellular and infection microbiology · 2024
    Article
  15. Review
  16. Resistance ofFrontiers in immunology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Lillian F ZhangDepartment of Medical Microbiology and Immunology, University of California at Davis, Davis, California, USA.
Bernd LepeniesInstitute for Immunology & Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine Hannover, Hanover, Germany.
Sayuri NakamaeDepartment of Immune Regulation, Shionogi Global Infectious Diseases Division, Institute of Tropical Medicine, Nagasaki Universitygrid.174567.6, Nagasaki, Japan.
Briana M YoungDepartment of Medical Microbiology and Immunology, University of California at Davis, Davis, California, USA.
Renato L SantosDepartment of Medical Microbiology and Immunology, University of California at Davis, Davis, California, USA.
Manuela RaffatelluDepartment of Pediatrics, School of Medicine, University of California San Diego, La Jolla, California, USA.ORCID 0000-0001-6487-4215
Brian A CobbDepartment of Pathology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Hirotaka HiyoshiDepartment of Medical Microbiology and Immunology, University of California at Davis, Davis, California, USA.
Andreas J BäumlerDepartment of Medical Microbiology and Immunology, University of California at Davis, Davis, California, USA.ORCID 0000-0001-9152-7809
Nagasaki University · JPCase Western Reserve University · USUniversity of California San Diego · USUniversity of Veterinary Medicine Hannover, Foundation · DE

Funding

Virulence Factors of SalmonellaR01AI044170 · NIAID · UNIVERSITY OF CALIFORNIA DAVIS · PI BAUMLER, ANDREAS J · 1999 to 2022
$8.5M
Exacerbation of colitis by the microbiotaR01AI112445 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Andreas J Baumler · 2015 to 2026
$6.2M
Microbiota Outgrowth by SalmonellaR01AI096528 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BAUMLER, ANDREAS J · 2011 to 2025
$6.1M
Mechanism of Colonization ResistanceR01AI112949 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Andreas J Baumler · 2016 to 2026
$5.2M
Salmonella pathogenicity island 2 triggers pore-induced intracellular trap formation to evade killing by neutrophilsR21AI143929 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HIYOSHI, HIROTAKA · 2020 to 2021
$432k
Dietary copper reconfigures pathogen growthR21AI146432 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BAUMLER, ANDREAS J · 2019 to 2020
$432k
Mechanism of E. coli colonization resistanceR56AI112949 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BAUMLER, ANDREAS J · 2014 to 2014
$382k
NIAID NIH HHS R01 AI044170NIAID NIH HHS R01 AI096528NIAID NIH HHS R01 AI112445NIAID NIH HHS R01 AI112949NIAID NIH HHS R21 AI143929NIAID NIH HHS R21 AI146432NIAID NIH HHS R56 AI112949
6 · The paper itself

Abstract

Capsular polysaccharides are common virulence factors of extracellular, but not intracellular bacterial pathogens, due to the antiphagocytic properties of these surface structures. It is therefore paradoxical that Salmonella enterica subspecies

Indexed as

Salmonella typhiTyphoid FeverDC-Specific ICAM-3 Grabbing NonintegrinHumansLectins, C-TypeMacrophagesPhagocytosisPolysaccharides, BacterialDC-Specific ICAM-3 Grabbing NonintegrinLectins, C-TypePolysaccharides, BacterialcapsuleC-type lectin receptorsSalmonellatyphoid fever

Identifiers

PMID36286551
PMCPMC9765441
OpenAlexW4307300263

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.