Evidence map›Paper›PMID 36286522›Full record

ArticlemBio2022

Antibiotic Acyldepsipeptides Stimulate the

Laura Reinhardt, Dhana Thomy, Markus Lakemeyer, Linda Maria Westermann, Joaquin Ortega, Stephan A Sieber, Peter Sass, Heike Brötz-Oesterhelt

Open access · goldAbstract read
In one paragraph

Article in mBio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

  1. ClpP2 modulates ClpXP assembly to promote multiple pathogenic phenotypes inProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Proteostasis-targeted antibacterial strategies.Journal of microbiology (Seoul, Korea) · 2026
    Review
  3. Polydatin as a natural ClpP modulator for combating methicillin-resistantFrontiers in cellular and infection microbiology · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Laura ReinhardtDepartment of Microbial Bioactive Compounds, Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingengrid.10392.39, Tübingen, Germany.
Dhana ThomyDepartment of Microbial Bioactive Compounds, Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingengrid.10392.39, Tübingen, Germany.
Markus LakemeyerDepartment of Chemistry, Technical University of Munich, Garching, Germany.
Linda Maria WestermannDepartment of Microbial Bioactive Compounds, Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingengrid.10392.39, Tübingen, Germany.
Joaquin OrtegaDepartment of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada.
Stephan A SieberDepartment of Chemistry, Technical University of Munich, Garching, Germany.ORCID 0000-0002-9400-906X
Peter Sass *Department of Microbial Bioactive Compounds, Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingengrid.10392.39, Tübingen, Germany.ORCID 0000-0002-4477-2382
Heike Brötz-Oesterhelt *Department of Microbial Bioactive Compounds, Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingengrid.10392.39, Tübingen, Germany.ORCID 0000-0001-9364-1832
University of Tübingen · DETechnical University of Munich · DEMcGill University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clp proteases consist of a proteolytic, tetradecameric ClpP core and AAA+ Clp-ATPases. Streptomycetes, producers of a plethora of secondary metabolites, encode up to five different ClpP homologs, and the composition of their unusually complex Clp protease machinery has remained unsolved. Here, we report on the composition of the housekeeping Clp protease in

Indexed as

StreptomycesAnti-Bacterial AgentsATPases Associated with Diverse Cellular ActivitiesBacterial ProteinsDepsipeptidesEndopeptidase ClpPeptide HydrolasesProteolysisProton-Translocating ATPasesacyldepsipeptidesAnti-Bacterial AgentsATPases Associated with Diverse Cellular ActivitiesBacterial ProteinsDepsipeptidesEndopeptidase ClpPeptide HydrolasesProton-Translocating ATPasesAAA+ chaperonesADEPantimicrobial agentscaseinolytic proteaseClp-ATPaseClpPmode of action

Identifiers

PMID36286522
PMCPMC9765437
OpenAlexW4307342464

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.