Evidence map›Paper›PMID 36286511›Full record

ArticleJournal of bacteriology2022

Characterization of M-Type-Specific Pilus Expression in Group A Streptococcus.

Roshika Roshika, Ira Jain, Theodore Glenaldo, Tyler Sickler, James M Musser, Paul Sumby

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of bacteriology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. The group AInfection and immunity · 2025
    Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Roshika RoshikaDepartment of Microbiology & Immunology, University of Nevada, Reno School of Medicine, Reno, Nevada, USA.
Ira JainDepartment of Microbiology & Immunology, University of Nevada, Reno School of Medicine, Reno, Nevada, USA.
Theodore GlenaldoDepartment of Microbiology & Immunology, University of Nevada, Reno School of Medicine, Reno, Nevada, USA.
Tyler SicklerDepartment of Microbiology & Immunology, University of Nevada, Reno School of Medicine, Reno, Nevada, USA.
James M MusserLaboratory of Molecular and Translational Human Infectious Disease Research, Center for Infectious Diseases, Department of Pathology and Genomic Medicine, Houston Methodist Research Institute and Houston Methodist Hospital, Houston, Texas, USA.
Paul SumbyDepartment of Microbiology & Immunology, University of Nevada, Reno School of Medicine, Reno, Nevada, USA.ORCID 0000-0002-0093-4159
University of Nevada, Reno · USHouston Methodist · US

Funding

Modulating the pathogenic potential of the group A StreptococcusR21AI139400 · NIAID · UNIVERSITY OF NEVADA RENO · PI SUMBY, PAUL · 2018 to 2019
$393k
The variable disease potential of group A Streptococcus isolates: a link to puerperal infectionsR21AI148813 · NIAID · UNIVERSITY OF NEVADA RENO · PI SUMBY, PAUL · 2020 to 2021
$393k
NIAID NIH HHS R21 AI139400NIAID NIH HHS R21 AI148813
6 · The paper itself

Abstract

In addition to providing a typing mechanism for group A Streptococcus (GAS) isolates (T typing), cell surface pilus production impacts GAS virulence characteristics, including adherence and immune evasion. The pilus biosynthesis genes are located in the fibronectin- and collagen-binding T-antigen (FCT) region of the genome, and nine different FCT types, encoding more than 20 different T types, have been described. GAS isolates are not uniform in their degree or pattern of pilus expression, as highlighted by pilus production being thermoregulated in isolates that harbor the FCT-type FCT-3 (e.g., M-types M3 and M49) but not in isolates that harbor FCT-2 (e.g., M-type M1). Here, we investigated the molecular basis underlying our previous finding that M3 GAS isolates produce pili in lower abundance than M1 or M49 isolates do. We discovered that, at least in part, the low pilus expression observed for M3 isolates is a consequence of the repression of pilus gene expression by the CovR/CovS two-component regulatory system and of an M3-specific mutation in the

Indexed as

Streptococcal InfectionsAdhesins, BacterialBacterial ProteinsFimbriae, BacterialGene Expression Regulation, BacterialHumansStreptococcus pyogenesAdhesins, BacterialBacterial Proteinsgene regulationpilistrain variationStreptococcus pyogenes

Identifiers

PMID36286511
PMCPMC9664953
OpenAlexW4307344143

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.