Evidence map›Paper›PMID 36286463›Full record

ReviewMarine drugs2022

Towards Sustainable Medicinal Resources through Marine Soft Coral Aquaculture: Insights into the Chemical Diversity and the Biological Potential.

Ngoc Bao An Nguyen, Lo-Yun Chen, Mohamed El-Shazly, Bo-Rong Peng, Jui-Hsin Su, Ho-Cheng Wu, I-Ta Lee, Kuei-Hung Lai

Open access · goldAbstract readReview
In one paragraph

Review in Marine drugs, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Analysis of Cembrane-Type Diterpenoids from Cultured Soft CoralInternational journal of molecular sciences · 2025
    Article
  3. Brianolide fromBiomolecules · 2025
    Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Ngoc Bao An NguyenGraduate Institute of Pharmacognosy, College of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan.
Lo-Yun ChenGraduate Institute of Pharmacognosy, College of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan.ORCID 0000-0003-3228-3933
Mohamed El-ShazlyDepartment of Pharmacognosy, Faculty of Pharmacy, Ain-Shams University, Organization of African Unity Street, Abassia, Cairo 11566, Egypt.
Bo-Rong PengGraduate Institute of Pharmacognosy, College of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan.ORCID 0000-0002-4537-1353
Jui-Hsin SuNational Museum of Marine Biology & Aquarium, Pingtung 94450, Taiwan.
Ho-Cheng WuGraduate Institute of Pharmacognosy, College of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan.ORCID 0000-0002-6648-6010
I-Ta LeeSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 11031, Taiwan.ORCID 0000-0002-8451-0280
Kuei-Hung LaiGraduate Institute of Pharmacognosy, College of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan.ORCID 0000-0001-7220-6356
Taipei Medical University · TWAin Shams University · EGNational Sun Yat-sen University · TWTaipei Medical University Hospital · TW

Funding

Ministry of Education DP2-111-21121-01-N-01-03National science and technology council MOST 111-2320-B-038-040-MY3Taipei Medical University TMU109-AE1-B15
6 · The paper itself

Abstract

In recent decades, aquaculture techniques for soft corals have made remarkable progress in terms of conditions and productivity. Researchers have been able to obtain larger quantities of soft corals, thus larger quantities of biologically active metabolites, allowing them to study their biological activity in many pharmacological assays and even produce sufficient quantities for clinical trials. In this review, we summarize 201 secondary metabolites that have been identified from cultured soft corals in the era from 2002 to September 2022. Various types of diterpenes (eunicellins, cembranes, spatanes, norcembranes, briaranes, and aquarianes), as well as biscembranes, sterols, and quinones were discovered and subjected to bioactivity investigations in 53 different studies. We also introduce a more in-depth discussion of the potential biological effects (anti-cancer, anti-inflammatory, and anti-microbial) and the mechanisms of action of the identified secondary metabolites. We hope this review will shed light on the untapped potential applications of aquaculture to produce valuable secondary metabolites to tackle current and emerging health conditions.

Indexed as

AnthozoaDiterpenesAnimalsAquacultureQuinonesSterolsDiterpenesQuinonesSterolsbiological functionscultured soft coralsdrug developmentsmedicinal resourcesecondary metabolites

Identifiers

PMID36286463
PMCPMC9604854
OpenAlexW4306391537

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.