Evidence map›Paper›PMID 36286436›Full record

ArticleMarine drugs2022

In Vitro Modulation of Complement Activation by Therapeutically Prospective Analogues of the Marine Polychaeta Arenicin Peptides.

Ilia A Krenev, Pavel V Panteleev, Ekaterina S Umnyakova, Nikolay P Gorbunov, Valeria A Kostevich, Sergey V Balandin, Tatiana V Ovchinnikova, Galina M Aleshina, Mikhail N Berlov

Open access · goldAbstract read
In one paragraph

Article in Marine drugs, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Ilia A KrenevDepartment of General Pathology and Pathological Physiology, Institute of Experimental Medicine, Academician Pavlov Street 12, 197376 Saint Petersburg, Russia.
Pavel V PanteleevM.M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya Street, 16/10, 117997 Moscow, Russia.ORCID 0000-0001-8448-031X
Ekaterina S UmnyakovaDepartment of General Pathology and Pathological Physiology, Institute of Experimental Medicine, Academician Pavlov Street 12, 197376 Saint Petersburg, Russia.
Nikolay P GorbunovDepartment of Molecular Genetics, Institute of Experimental Medicine, Academician Pavlov Street 12, 197376 Saint Petersburg, Russia.ORCID 0000-0003-4636-0565
Valeria A KostevichDepartment of Molecular Genetics, Institute of Experimental Medicine, Academician Pavlov Street 12, 197376 Saint Petersburg, Russia.
Sergey V BalandinM.M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya Street, 16/10, 117997 Moscow, Russia.ORCID 0000-0003-2651-3739
Tatiana V OvchinnikovaM.M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya Street, 16/10, 117997 Moscow, Russia.ORCID 0000-0002-5950-249X
Galina M AleshinaDepartment of General Pathology and Pathological Physiology, Institute of Experimental Medicine, Academician Pavlov Street 12, 197376 Saint Petersburg, Russia.
Mikhail N BerlovDepartment of General Pathology and Pathological Physiology, Institute of Experimental Medicine, Academician Pavlov Street 12, 197376 Saint Petersburg, Russia.ORCID 0000-0001-5191-0467
Institute of Experimental Medicine · RUInstitute of Bioorganic Chemistry · RUSechenov University · RUUniversity of Basel · CH

Funding

Ministry of Science and Higher Education of the Russian Federation 0557-2019-0010Ministry of Science and Higher Education of the Russian Federation FGWG-2022-0007Russian Science Foundation 22-14-00380
6 · The paper itself

Abstract

The widespread resistance to antibiotics in pathogenic bacteria makes the development of a new generation of antimicrobials an urgent task. The development of new antibiotics must be accompanied by a comprehensive study of all of their biological activities in order to avoid adverse side-effects from their application. Some promising antibiotic prototypes derived from the structures of arenicins, antimicrobial peptides from the lugworm

Indexed as

PolychaetaAnimalsAnti-Bacterial AgentsAntimicrobial Cationic PeptidesComplement ActivationHelminth ProteinsHumansPolystyrenesProspective StudiesAmberlite XAD-2 resinAnti-Bacterial AgentsAntimicrobial Cationic PeptidesHelminth ProteinsPolystyrenesantibioticsantimicrobial peptidesarenicinscomplement system

Identifiers

PMID36286436
PMCPMC9605166
OpenAlexW4297478146

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.