Evidence map›Paper›PMID 36286302›Full record

ReviewJournal of cardiovascular development and disease2022

Multimodality Imaging in the Detection of Ischemic Heart Disease in Women.

Sean Paul Gaine, Garima Sharma, Albree Tower-Rader, Mina Botros, Lara Kovell, Anushri Parakh, Malissa J Wood, Colleen M Harrington

Open access · goldAbstract readReview
In one paragraph

Review in Journal of cardiovascular development and disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Sex-Specific Coronary Artery Calcium Score Threshold Predictive of Obstructive Coronary Artery Disease.Journal of the Society for Cardiovascular Angiography & Interventions · 2026
    Article
  2. Article
  3. Guideline for Chronic Coronary Syndrome - 2025.Arquivos brasileiros de cardiologia · 2025
    Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Sean Paul GaineDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.ORCID 0000-0002-9753-3916
Garima SharmaDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Albree Tower-RaderDepartment of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA.
Mina BotrosDepartment of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Lara KovellDepartment of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Anushri ParakhDepartment of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA.
Malissa J WoodDivision of Cardiology, Massachusetts General Hospital, Boston, MA 02214, USA.
Colleen M HarringtonDepartment of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Massachusetts General Hospital · USUniversity of Massachusetts Chan Medical School · USJohns Hopkins University · US

Funding

Training In Cardiovascular Physiology & PharmacologyT32HL007444 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ju Chen, Robert Scott Ross · 1985 to 2026
$11.1M
UCSD PRIDE Faculty Development Program in Cardiovascular SciencesR25HL145817 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Robert Scott Ross, Joann Trejo · 2019 to 2026
$3.3M
NHLBI NIH HHS R25 HL145817NHLBI NIH HHS T32 HL007444
6 · The paper itself

Abstract

Women with coronary artery disease tend to have a worse short and long-term prognosis relative to men and the incidence of atherosclerotic cardiovascular disease is increasing. Women are less likely to present with classic anginal symptoms when compared with men and more likely to be misdiagnosed. Several non-invasive imaging modalities are available for diagnosing ischemic heart disease in women and many of these modalities can also assist with prognostication and help to guide management. Selection of the optimal imaging modality to evaluate women with possible ischemic heart disease is a scenario which clinicians often encounter. Earlier modalities such as exercise treadmill testing demonstrate significant performance variation in men and women, while newer modalities such as coronary CT angiography, myocardial perfusion imaging and cardiac magnetic resonance imaging are highly specific and sensitive for the detection of ischemia and coronary artery disease with greater parity between sexes. Individual factors, availability, diagnostic performance, and female-specific considerations such as pregnancy status may influence the decision to select one modality over another. Emerging techniques such as strain rate imaging, CT-myocardial perfusion imaging and cardiac magnetic resonance imaging present additional options for diagnosing ischemia and coronary microvascular dysfunction.

Indexed as

ischemic heart diseasenoninvasive imagingstress testing cardiovascular disease in women

Identifiers

PMID36286302
PMCPMC9604786
OpenAlexW4306152282

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.