ReviewEmerging topics in life sciences2022
Negative valence systems: sustained threat and the predatory imminence continuum.
Review in Emerging topics in life sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Unveiling the enigma of anxiety disorders and depression: from pathogenesis to treatment.Science China. Life sciences · 2026Review
- Second-order conditioning of safety in male and female rats.Behavioural brain research · 2026Article
- Hippocampal representations differentiate reactive and anticipatory responses during foraging under threat.bioRxiv : the preprint server for biology · 2026Article
- How Temporal Predictability of Threat and Action Preparation Affect Defensive Freezing Responses.Psychophysiology · 2026Article
- Article
- Neural anticipation of virtual infection triggers an immune response.Nature neuroscience · 2025Article
- An integrative assay for measuring social aversion and motivation in freely behaving mice.Cell reports methods · 2025Article
- I'm Still Standing: Body Sway, Interpersonal Distance, and Social Anxiety - A Proof of Principle.Clinical psychology in Europe · 2025Article
- Defensive behaviors and c-fos expression in the midbrain.Integrative zoology · 2025Article
- No effect of partial reinforcement on fear extinction learning and memory in C57BL/6J mice.Learning & memory (Cold Spring Harbor, N.Y.) · 2025Article
- The Intersection of Interoception and Anticipation Related to Pain.Current topics in behavioral neurosciences · 2025Review
- Engrams: From Behavior to Brain-Wide Networks.Advances in neurobiology · 2024Review
- PAC1 receptor modulation of freezing and flight behavior in periaqueductal gray.Genes, brain, and behavior · 2023Article
- Defensive responses: behaviour, the brain and the body.Nature reviews. Neuroscience · 2023Review
- Bed nucleus of the stria terminalis GABA neurons are necessary for changes in foraging behaviour following an innate threat.The European journal of neuroscience · 2023Article
- Beyond Nature Versus Nurture: the Emergence of Emotion.Affective science · 2023Review
- Bed Nucleus of the Stria Terminalis GABA neurons are necessary for changes in foraging behavior following an innate threat.bioRxiv : the preprint server for biology · 2023Article
- Beyond Fear, Extinction, and Freezing: Strategies for Improving the Translational Value of Animal Conditioning Research.Current topics in behavioral neurosciences · 2023Article
- Fear, defense, and emotion: A neuroethological understanding of the negative valence research domain criteria.The American psychologistArticle
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Abstract
This review describes the relationship between the National Institute of Mental Health (U.S.A.) Research Domain Criteria (RDoC) Negative Valence System related to responses to threat and the Predatory Imminence Continuum model of antipredator defensive behavior. While the original RDoC constructs of Potential Threat (anxiety) and Acute Threat (fear) fit well with the pre-encounter and post-encounter defense modes of the predatory imminence model, the Sustained Threat construct does not. Early research on the bed nuclei of the stria terminalis (BST) suggested that when fear responding needed to be sustained for a prolonged duration this region was important. However, follow-up studies indicated that the BST becomes critical not because responses needed to be sustained but rather when the stimuli triggering fear were more difficult to learn about, particularly when aversive stimuli were difficult to accurately predict. Instead, it is argued that the BST and the hippocampus act to expand the range of conditions that can trigger post-encounter defense (Acute Threat). It is further suggested that sustained threat refers to situations where the predatory imminence continuum becomes distorted causing defensive behavior to intrude into times when organisms should be engaging in other adaptive behaviors. Stress is seen as something that can cause a long-term disturbance of the continuum and this disturbance is a state of sustained threat.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.