Evidence map›Paper›PMID 36286201›Full record

ArticleInfectious disease reports2022

Efficacy of COVID-19 Vaccination in People Living with HIV: A Public Health Fundamental Tool for the Protection of Patients and the Correct Management of Infection.

Alessio Facciolà, Smeralda D'Amato, Sebastiano Calimeri, Daniela Lo Giudice, Cristina Micali, Ylenia Russotto, Emmanuele Venanzi Rullo, Giuseppe Nunnari, Raffaele Squeri, Giovanni Francesco Pellicanò

Abstract read
In one paragraph

Article in Infectious disease reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alessio FacciolàDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98124 Messina, Italy.
Smeralda D'AmatoDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98124 Messina, Italy.
Sebastiano CalimeriDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98124 Messina, Italy.
Daniela Lo GiudiceDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98124 Messina, Italy.
Cristina MicaliDepartment of Clinical and Experimental Medicine, University of Messina, 98124 Messina, Italy.ORCID 0000-0001-6753-6676
Ylenia RussottoDepartment of Clinical and Experimental Medicine, University of Messina, 98124 Messina, Italy.ORCID 0000-0001-9514-133X
Emmanuele Venanzi RulloDepartment of Clinical and Experimental Medicine, University of Messina, 98124 Messina, Italy.ORCID 0000-0001-8273-5382
Giuseppe NunnariDepartment of Clinical and Experimental Medicine, University of Messina, 98124 Messina, Italy.ORCID 0000-0002-8113-8452
Raffaele SqueriDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98124 Messina, Italy.
Giovanni Francesco PellicanòDepartment of Human Pathology of the Adult and the Developmental Age "G. Barresi", University of Messina, 98124 Messina, Italy.ORCID 0000-0002-9640-8742

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

HIV/AIDS is considered a risk factor for increased mortality due to COVID-19. For this reason, it is essential to include this population in vaccination campaigns. Studies found that antibodies are lower in HIV+ patients than in healthy individuals. The aim of this study was to assess the immune response in a cohort of people living with HIV/AIDS (PLWH) vaccinated with COVID-19 vaccination in order to evaluate the role played by the HIV infection in the efficacy of this vaccine. We carried out a cross-sectional study in the period April-September 2021, involving a cohort of PLWH and a cohort of HIV-uninfected people as the control group. The efficacy of vaccination was high in both groups despite a slight and not significant difference between them. However, important differences were found according to the intensity of the immune response. Specifically, while in the HIV+ group almost a quarter of people had a low response, it is important to remark that the control group had only a high or intermediate response after vaccination. Our results suggest the high efficacy of the mRNA COVID-19 vaccine in PLWH and the importance to vaccinate against COVID-19 in these patients in order to increase their protection.

Indexed as

COVID-19efficacyHIV/AIDSvaccination

Identifiers

PMID36286201
PMCPMC9602118

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.