Evidence map›Paper›PMID 36285978›Full record

ArticleAdvances in respiratory medicine2022

Nasal Nitric Oxide Levels: Improving the Diagnosis of Primary Ciliary Dyskinesia in Puerto Rico.

Wilfredo De Jesús-Rojas, Francisco Alvarado-Huerta, Jesús M Meléndez-Montañez, José Muñiz-Hernández, Arnaldo Santos-López, Ricardo A Mosquera

Open access · goldAbstract read
In one paragraph

Article in Advances in respiratory medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. TheInternational journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Wilfredo De Jesús-RojasDepartment of Pediatrics-Anatomy and Neuroanatomy, University of Puerto Rico, Medical Sciences Campus, San Juan, PR 00921, USA.ORCID 0000-0002-6133-3517
Francisco Alvarado-HuertaDepartment of Pediatrics-Anatomy and Neuroanatomy, University of Puerto Rico, Medical Sciences Campus, San Juan, PR 00921, USA.
Jesús M Meléndez-MontañezDepartment of Pediatrics and Basic Science, Ponce Health Science University, Ponce, PR 00716, USA.
José Muñiz-HernándezDepartment of Natural Science, University of Puerto Rico, Cayey Campus, Cayey, PR 00736, USA.
Arnaldo Santos-LópezDepartment of Pediatrics and Basic Science, Ponce Health Science University, Ponce, PR 00716, USA.
Ricardo A MosqueraDepartment of Pediatrics, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Ponce Health Sciences University · PRUniversity of Puerto Rico, Medical Sciences Campus · PRThe University of Texas Health Science Center at Houston · USUniversity of Puerto Rico at Cayey · PR

Funding

Hispanics in Research Capability: SoHP & SOM Partnership (HIREC)S21MD001830 · NIMHD · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI ELIAS BONETA, AUGUSTO R, ESTAPE, ESTELA S · 2005 to 2010
$30.0M
Hispanic Clinical and Translational Research Education and Career Development ProgramR25MD007607 · NIMHD · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI Karen G. Martinez Gonzalez, Barbara Segarra-Vazquez · 2012 to 2026
$7.4M
Hispanic Center of Excellence D34HP24463National Institute of Minority Health and Health Disparities R25MD007607NIMHD NIH HHS R25 MD007607NIMHD NIH HHS S21 MD001830Puerto Rico Science, Technology & Research Trust PRSTRT: 2022-00012AUPRMSC Hispanics-In-Research Capability (HiREC) Endowment S21MD001830
6 · The paper itself

Abstract

Primary Ciliary Dyskinesia (PCD) is a rare genetic disease characterized by motile cilia dysfunction with a prevalence of 1 in 16,309 individuals in Hispanic populations. In Puerto Rico, the prevalence of PCD is unknown. Diagnosis of PCD in Puerto Rico is challenging due to the lack of diagnostic technology. Algorithms for PCD diagnosis include clinical history, genetic testing, ciliary biopsy, and nasal Nitric Oxide (nNO) levels. For the first time, this study successfully implemented and measured the nNO levels in subjects with the

Indexed as

Ciliary Motility DisordersNitric OxideHumansMutationNosePuerto RicoNitric Oxideciliafounder mutationgenotypenasal Nitric OxidephenotypePrimary Ciliary DyskinesiaPuerto RicoRSPH4A

Identifiers

PMID36285978
PMCPMC9717333
OpenAlexW4298001605

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.