Evidence map›Paper›PMID 36285843›Full record

ArticleOrganic & biomolecular chemistry2022

Serine-γPNA, Invader probes, and chimeras thereof: three probe chemistries that enable sequence-unrestricted recognition of double-stranded DNA.

Raymond G Emehiser, Karishma Dhuri, Caroline Shepard, Saswata Karmakar, Raman Bahal, Patrick J Hrdlicka

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Organic & biomolecular chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Gamma-FIT-PNAs as sensitive RNA probes.RSC chemical biology · 2026
    Article
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  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Raymond G EmehiserDepartment of Chemistry, University of Idaho, Moscow, ID-83844, USA. hrdlicka@uidaho.edu.
Karishma DhuriPharmaceutical Sciences, University of Connecticut, Storrs, CT-06269, USA.
Caroline ShepardDepartment of Chemistry, University of Idaho, Moscow, ID-83844, USA. hrdlicka@uidaho.edu.
Saswata KarmakarDepartment of Chemistry, University of Idaho, Moscow, ID-83844, USA. hrdlicka@uidaho.edu.
Raman BahalPharmaceutical Sciences, University of Connecticut, Storrs, CT-06269, USA.ORCID 0000-0002-5943-4861
Patrick J HrdlickaDepartment of Chemistry, University of Idaho, Moscow, ID-83844, USA. hrdlicka@uidaho.edu.ORCID 0000-0002-8113-0450

Funding

Developing next generation synthetic nucleic acid analogous for sickle cell disease gene editingR01HL147028 · NHLBI · UNIVERSITY OF CONNECTICUT STORRS · PI BAHAL, RAMAN · 2020 to 2024
$2.0M
Invader LNAs as Novel Gene Specific TherapeuticsR01GM088697 · NIGMS · UNIVERSITY OF IDAHO · PI HILL, RODNEY ALLAN, HRDLICKA, PATRICK J. · 2009 to 2011
$519k
HSRD VA PEC 13-001NHLBI NIH HHS R01 HL147028NIGMS NIH HHS R01 GM088697
6 · The paper itself

Abstract

Three probe chemistries are evaluated with respect to thermal denaturation temperatures, UV-Vis and fluorescence characteristics, recognition of complementary and mismatched DNA hairpin targets, and recognition of chromosomal DNA targets in the context of non-denaturing fluorescence

Indexed as

Peptide Nucleic AcidsSerineDNADNA ProbesIn Situ Hybridization, FluorescenceRNADNADNA ProbesPeptide Nucleic AcidsRNASerine

Identifiers

PMID36285843
PMCPMC9707317

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.