Evidence map›Paper›PMID 36285717›Full record

ArticleThe Journal of physiology2023

Distinct type I collagen alterations cause intrinsic lung and respiratory defects of variable severity in mouse models of osteogenesis imperfecta.

Milena Dimori, Jordan Fett, Sergey Leikin, Satoru Otsuru, Jeff D Thostenson, John L Carroll, Roy Morello

Open access · greenAbstract read
In one paragraph

Article in The Journal of physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Cardiac health, type I collagen, and aging in theAmerican journal of physiology. Heart and circulatory physiology · 2025
    Article
  5. A new Col1a1 conditional knock-in mouse model to study osteogenesis imperfecta.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024
    Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Milena DimoriDepartment of Physiology & Cell Biology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Jordan FettDepartment of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Sergey LeikinSection on Physical Biochemistry, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), NIH, Bethesda, MD, USA.
Satoru OtsuruDepartment of Orthopaedics, University of Maryland School of Medicine, Baltimore, MD, USA.
Jeff D ThostensonDepartment of Biostatistics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
John L CarrollDepartment of Physiology & Cell Biology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.ORCID 0000-0001-7492-3260
Roy MorelloDepartment of Physiology & Cell Biology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.ORCID 0000-0003-1604-4879
University of Arkansas for Medical Sciences · USEunice Kennedy Shriver National Institute of Child Health and Human Development · USUniversity of Maryland, Baltimore · US

Funding

Understanding the Negative Prognostic Impact of Intraosseous Focal Lesions in Multiple MyelomaP20GM125503 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI CHARLES A O'BRIEN · 2018 to 2026
$23.0M
Collagen-related diseases ZIAHD000256 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI LEIKIN, SERGEY · 2009 to 2025
$19.7M
Expanding Translational Research in ArkansasU54TR001629 · NCATS · UNIV OF ARKANSAS FOR MED SCIS · PI JAMES, LAURA P · 2017 to 2017
$3.5M
Primary lung defects in mouse models of osteogenesis imperfectaR03HD097559 · NICHD · UNIV OF ARKANSAS FOR MED SCIS · PI MORELLO, ROY · 2019 to 2020
$151k
NCATS NIH HHS U54 TR001629NICHD NIH HHSNICHD NIH HHS R03 HD097559NIGMS NIH HHS P20 GM125503
6 · The paper itself

Abstract

Type I collagen alterations cause osteogenesis imperfecta (OI), a connective tissue disorder characterized by severe bone fragility. Patients with OI can suffer from significant pulmonary manifestations including severe respiratory distress in the neonatal period and a progressive decline in respiratory function in adulthood. We and others have shown intrinsic lung defects in some mouse models of OI. In this large study, we performed histological, histomorphometric, microcomputed tomography and invasive studies on oim/+, Col1a2

Indexed as

Collagen Type IOsteogenesis ImperfectaAnimalsDisease Models, AnimalFemaleLungMaleMiceX-Ray MicrotomographyCollagen Type ICollagen Type I, alpha2 Subunitcollagenlungmouse modelsosteogenesis imperfectarespiratory function

Identifiers

PMID36285717
PMCPMC9840670
OpenAlexW4307503404

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.