Evidence map›Paper›PMID 36285495›Full record

ArticleProceedings. Biological sciences2022

Disentangling the developmental origins of a novel phenotype: enhancement versus reversal of environmentally induced gene expression.

Nicholas A Levis, Daniel J McKay, David W Pfennig

Open access · greenAbstract read
In one paragraph

Article in Proceedings. Biological sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Nicholas A LevisDepartment of Biology, University of North Carolina, Chapel Hill, NC 27599, USA.ORCID 0000-0001-7650-2371
Daniel J McKayDepartment of Biology, University of North Carolina, Chapel Hill, NC 27599, USA.
David W PfennigDepartment of Biology, University of North Carolina, Chapel Hill, NC 27599, USA.ORCID 0000-0002-1114-534X
University of North Carolina at Chapel Hill · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Increasing evidence suggests that many novel traits might have originated via plasticity-led evolution (PLE). Yet, little is known of the developmental processes that underpin PLE, especially in its early stages. One such process is 'phenotypic accommodation', which occurs when, in response to a change in the environment, an organism experiences adjustments across variable parts of its phenotype that improve its fitness. Here, we asked if environmentally induced changes in gene expression are enhanced or reversed during phenotypic accommodation of a novel, complex phenotype in spadefoot toad tadpoles (

Indexed as

AnuraBiological EvolutionAdaptation, PhysiologicalAnimalsGene ExpressionLarvaPhenotypegene expressionphenotypic accommodationphenotypic plasticityplasticity-led evolutionspadefoot toad

Identifiers

PMID36285495
PMCPMC9597403
OpenAlexW4307429791

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.