Evidence map›Paper›PMID 36285307›Full record

ArticleCyborg and bionic systems (Washington, D.C.)2022

Cell-Based Microfluidic Device Utilizing Cell Sheet Technology.

Katsuhisa Sakaguchi, Kei Akimoto, Masanori Takaira, Ryu-Ichiro Tanaka, Tatsuya Shimizu, Shinjiro Umezu

Abstract read
In one paragraph

Article in Cyborg and bionic systems (Washington, D.C.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Katsuhisa SakaguchiDepartment of Integrative Bioscience and Biomedical Engineering, Graduate School of Advanced Science and Engineering, TWIns, Waseda University, 2-2 Wakamatsu-Cho, Shinju-Ku, Tokyo 162-8480, Japan.ORCID https://orcid.org/0000-0002-8610-8455
Kei AkimotoDepartment of Modern Mechanical Engineering, Graduate School of Creative Science and Engineering, Waseda University, 1-104 Totsuka-Cho, Shinju-Ku, Tokyo 169-8555, Japan.
Masanori TakairaDepartment of Modern Mechanical Engineering, Graduate School of Creative Science and Engineering, Waseda University, 1-104 Totsuka-Cho, Shinju-Ku, Tokyo 169-8555, Japan.
Ryu-Ichiro TanakaInstitute of Advanced Biomedical Engineering and Science, TWIns, Tokyo Women's Medical University, 8-1 Kawada-Cho, Shinju-Ku, Tokyo 162-8666, Japan.
Tatsuya ShimizuInstitute of Advanced Biomedical Engineering and Science, TWIns, Tokyo Women's Medical University, 8-1 Kawada-Cho, Shinju-Ku, Tokyo 162-8666, Japan.ORCID https://orcid.org/0000-0001-7601-4239
Shinjiro UmezuDepartment of Integrative Bioscience and Biomedical Engineering, Graduate School of Advanced Science and Engineering, TWIns, Waseda University, 2-2 Wakamatsu-Cho, Shinju-Ku, Tokyo 162-8480, Japan.ORCID https://orcid.org/0000-0003-2146-5344

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of microelectromechanical systems has resulted in the rapid development of polydimethylpolysiloxane (PDMS) microfluidic devices for drug screening models. Various cell functions, such as the response of endothelial cells to fluids, have been elucidated using microfluidic devices. Additionally, organ-on-a-chip systems that include organs that are important for biological circulation, such as the heart, liver, pancreas, kidneys, and brain, have been developed. These organs realize the biological circulation system in a manner that cannot be reproduced by artificial organs; however, the flow channels between the organs are often artificially created by PDMS. In this study, we developed a microfluidic device consisting only of cells, by combining cell sheet technology with microtitanium wires. Microwires were placed between stacked fibroblast cell sheets, and the cell sheets adhered to each other, after which the microwires were removed leaving a luminal structure with a size approximately equal to the arteriolar size. The lumen structure was constructed using wires with diameters of 50, 100, 150, and 200

Identifiers

PMID36285307
PMCPMC9494697

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.