Evidence map›Paper›PMID 36284944›Full record

ArticleArchives of Razi Institute2022

Evaluation of Oxidative Stress Parameters and Antioxidant Status in Coronary Artery Disease Patients.

S Varadhan, R Venkatachalam, S M Perumal, S S Ayyamkulamkara

Open access · greenAbstract read
In one paragraph

Article in Archives of Razi Institute, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

S VaradhanDepartment of Biochemistry, Bharath Institute of Higher Education and Research, Selaiyur, Chennai, Tamil Nadu, India.
R VenkatachalamDepartment of Biochemistry, Sreelekshmi Narayana Institute of Medical Science, Bharath Institute of Higher Education and Research, Puducherry, India.
S M PerumalDepartment of Pharmacology, Tagore Dental College and Hospital, Chennai, Tamil Nadu, India.
S S AyyamkulamkaraDepartment of Biochemistry, Government Medical College, Trissur, Kerala, India.
Bharath University · INGovernment of Kerala · INTamil Nadu Government Dental College and Hospital · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A surge in oxidative stress and weakened antioxidant defense contributes to the initiation and progression of Coronary Artery Diseases (CAD). The resultant burst in free radicals causes oxidation of lipoproteins mainly oxidized low-density lipoprotein (oxLDL). Further studies need to be conducted to find whether the management of CAD can be evaluated within the context of oxidant/antioxidant balance with the contribution of newer markers. This study was performed to evaluate, compare, and correlate oxidative stress parameters and antioxidant status in CAD patients with controls and evaluate and compare pro-oxidant, a pro-inflammatory enzyme, myeloperoxidase (MPO) and anti-oxidant, anti-inflammatory enzyme, and paraoxonase (PON) between CAD patients and controls. OxLDL, an oxidation product of low-density lipoprotein, malondialdehyde (MDA), an oxidative marker, and reduced glutathione (GSH), an anti-oxidant marker, and lipid profile were assessed and compared in CAD patients and controls. The activity of MPO was correlated with that of PON, and MDA level was correlated with GSH level. A total of 100 clinically proven CAD patients, in the age range of 35-70 years, were selected from the Out Patient Department (OPD) of our Institute. A total of 60 controls in the same age range and without CAD were selected after undergoing health checkups in the hospital. Based on the obtained results, oxLDL, MDA, and MPO were significantly increased in patients than in controls (

Indexed as

AntioxidantsCoronary Artery DiseaseAdultAgedAryldialkylphosphataseBiomarkersCholesterolGlutathioneHumansLipoproteinsLipoproteins, LDLMalondialdehydeMiddle AgedOxidative StressPeroxidaseReactive Oxygen SpeciesAntioxidantsAryldialkylphosphataseBiomarkersCholesterolGlutathioneLipoproteinsLipoproteins, LDLMalondialdehydePeroxidaseReactive Oxygen SpeciesTriglyceridesCoronary artery diseaseMalondialdehydeMyeloperoxidaseOxidized low-density lipoproteinParaoxonase

Identifiers

PMID36284944
PMCPMC9548289
OpenAlexW4307502718

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.