ArticleArchives of Razi Institute2022
An Examination of the Effect of Rutin against Neurotoxicity Induced by Ciprofloxacin Antibiotic in Wistar Rats.
Article in Archives of Razi Institute, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 7 citations in OpenAlex.
- Glucosamine/chitosan blend surface-engineered rutin-loaded polymer/lipid hybrid nanoparticles for neuroprotection in induced schizophrenia model.Scientific reports · 2026Article
- Rutin outperforms gallic acid in mitigating carbon tetrachloride-induced nephrotoxicity: Integrated in silico (docking, MD simulations, DFT) and in vivo mechanistic validation.Toxicology reports · 2026Article
- Evaluation of the protective effect of quercetin and luteolin against ciprofloxacin- and chloramphenicol-induced oxidative stress in blood cells and their impact on the microbiological activity.Frontiers in pharmacology · 2025Article
- Understanding CNS Effects of Antimicrobial Drugs Using Zebrafish Models.Veterinary sciences · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rutin is a citrus flavonoid that exists in different types of food, such as fruits, tea, as well as vegetables, and is considered a natural antioxidant. This study aimed to investigate the therapeutic role of Rutin in oxidative stress-induced in Wistar rats exposed to Ciprofloxacin (CPX). The study included 36 healthy adult Wistar rats, which were randomly divided into six groups (n=6). The control group (C) received normal drinking water for 20 days. The first treatment group (T1) received Rutin at a dose of 50 mg/kg of b.w for 20 days. The second treatment group (T2) received CPX antibiotic at a dose of 14 mg/kg of b.w for 20 days. The third treatment group (T3) received Rutin at a dose of 50 mg/kg of b.w for 20 days, and afterward, they received CPX antibiotic at a dose of 14 mg/kg of b.w for 20 days. The fourth treatment group (T4) received CPX antibiotic at a dose of 14 mg/kg of b.w for 20 days, and then, they received Rutin at a dose of 50 mg/kg of b.w for 20 days. The fifth treatment group (T5) received CPX antibiotic at a dose of 14 mg/ kg of b.w and Rutin at a dose of 50 mg/ kg of b.w together for 20 days. All the treatments were administrated by oral gavage. Analysis of the recorded data showed a significant increase (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.