Evidence map›Paper›PMID 36284928›Full record

ArticleTransplantation direct2022

Patient and Graft Survival After A1/A2-incompatible Living Donor Kidney Transplantation.

Shivani S Bisen, Samantha N Getsin, Po-Yu Chiang, Kayleigh Herrick-Reynolds, Laura B Zeiser, Sile Yu, Niraj M Desai, Fawaz Al Ammary, Kyle R Jackson, Dorry L Segev and 1 more

Open access · goldAbstract read
In one paragraph

Article in Transplantation direct, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Shivani S BisenGrossman School of Medicine, New York University, New York, NY.
Samantha N GetsinDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.
Po-Yu ChiangGrossman School of Medicine, New York University, New York, NY.
Kayleigh Herrick-ReynoldsDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.
Laura B ZeiserGrossman School of Medicine, New York University, New York, NY.
Sile YuDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.
Niraj M DesaiDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.
Fawaz Al AmmaryDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.
Kyle R JacksonDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.
Dorry L SegevGrossman School of Medicine, New York University, New York, NY.
Allan B MassieGrossman School of Medicine, New York University, New York, NY.
Johns Hopkins University · USNew York University · USJohns Hopkins Medicine · US

Funding

Telemedicine for Evaluation and Counseling of Living Kidney Donor CandidatesK23DK129820 · NIDDK · UNIVERSITY OF CALIFORNIA-IRVINE · PI AL AMMARY, FAWAZ · 2021 to 2025
$985k
Patient Oriented Research in Solid Organ TransplantationK24AI144954 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SEGEV, DORRY L. · 2020 to 2024
$956k
Determinants of chronic kidney disease in African-American live kidney donorsK01DK101677 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI MASSIE, ALLAN B · 2015 to 2019
$789k
NIAID NIH HHS K24 AI144954NIDDK NIH HHS K01 DK101677NIDDK NIH HHS K23 DK129820
6 · The paper itself

Abstract

ABO type B and O kidney transplant candidates have increased difficulty identifying a compatible donor for living donor kidney transplantation (LDKT) and are harder to match in kidney paired donation registries. A2-incompatible (A2i) LDKT increases access to LDKT for these patients. To better inform living donor selection, we evaluated the association between A2i LDKT and patient and graft survival. Methods: We used weighted Cox regression to compare mortality, death-censored graft failure, and all-cause graft loss in A2i versus ABO-compatible (ABOc) recipients. Results: Using Scientific Registry of Transplant Recipients data 2000-2019, we identified 345 A2i LDKT recipients. Mortality was comparable among A2i and ABOc recipients; weighted 1-/5-/10-y mortality was 0.9%/6.5%/24.2%, respectively, among A2i LDKT recipients versus 1.4%/7.7%/22.2%, respectively, among ABOc LDKT recipients (weighted hazard ratio [wHR], Conclusions: A2i LDKT is generally safe, but A2i donor/recipient pairs should be counseled about the increased risk of graft failure and be monitored as closely as their A1-incompatible counterparts posttransplant.

Identifiers

PMID36284928
PMCPMC9584180
OpenAlexW4307495128

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.