Evidence map›Paper›PMID 36284901›Full record

ArticleImmunotherapy advances2021

Vitamin D

Emma S Chambers, Milica Vukmanovic-Stejic, Carolin T Turner, Barbara B Shih, Hugh Trahair, Gabriele Pollara, Evdokia Tsaliki, Malcolm Rustin, Tom C Freeman, Neil A Mabbott and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunotherapy advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 29 citations in OpenAlex.

  1. Trial
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  5. Article
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  10. Article
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  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Immunotherapy advances: One year on.Immunotherapy advances · 2022
    Article
  18. Extreme immunotherapy: emergency immunology to defeat pandemics.Molecular medicine (Cambridge, Mass.) · 2021
    Article
  19. IntroducingImmunotherapy advances · 2021
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Emma S ChambersCentre for Immunobiology, Blizard Institute, Queen Mary University of London, London, UK.ORCID 0000-0003-0990-8835
Milica Vukmanovic-StejicDivision of Infection and Immunity, University College London, London, UK.
Carolin T TurnerDivision of Infection and Immunity, University College London, London, UK.
Barbara B ShihThe Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, UK.ORCID 0000-0002-3676-3304
Hugh TrahairDivision of Medicine, University College London, London, UK.
Gabriele PollaraDivision of Infection and Immunity, University College London, London, UK.ORCID 0000-0001-5772-0322
Evdokia TsalikiDivision of Infection and Immunity, University College London, London, UK.
Malcolm RustinDepartment of Dermatology, Royal Free Hospital, London, UK.
Tom C FreemanThe Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, UK.
Neil A MabbottThe Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, UK.
Mahdad NoursadeghiDivision of Infection and Immunity, University College London, London, UK.ORCID 0000-0002-4774-0853
Adrian R MartineauCentre for Immunobiology, Blizard Institute, Queen Mary University of London, London, UK.
Arne N AkbarDivision of Medicine, University College London, London, UK.
University College London · GBRoslin Institute · GBQueen Mary University of London · GBThe Royal Free Hospital · GB

Funding

Medical Research Council MR/M003833/1
6 · The paper itself

Abstract

Introduction: Ageing is associated with increased number of infections, decreased vaccine efficacy and increased systemic inflammation termed inflammageing. These changes are reflected by reduced recall responses to varicella zoster virus (VZV) challenge in the skin of older adults. Vitamin D deficiency is more common in the old and has been associated with frailty and increased inflammation. In addition, vitamin D increases immunoregulatory mechanisms and therefore has the potential to inhibit inflammageing. Objectives: We investigated the use of vitamin D Methods: Vitamin D insufficient older adults ( Results: We showed that older adults had reduced VZV-specific cutaneous immune response and increased non-specific inflammation as compared to young. Increased non-specific inflammation observed in the skin of older adults negatively correlated with vitamin D sufficiency. We showed that vitamin D Conclusion: Vitamin D

Indexed as

ageingskinvaricella zoster virusvitamin D

Identifiers

PMID36284901
PMCPMC9585673
OpenAlexW3109961926

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.