Evidence map›Paper›PMID 36284701›Full record

ArticleInnovation in aging2022

Estimated Pulse Wave Velocity and All-Cause Mortality: Findings From the Health and Retirement Study.

Kevin S Heffernan, Janet M Wilmoth, Andrew S London

Abstract read
In one paragraph

Article in Innovation in aging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

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  4. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kevin S HeffernanDepartment of Exercise Science, Falk College of Sport and Human Dynamics, Syracuse University, Syracuse, New York, USA.ORCID https://orcid.org/0000-0002-3499-1477
Janet M WilmothThe Aging Studies Institute, Syracuse University, Syracuse, New York, USA.
Andrew S LondonThe Aging Studies Institute, Syracuse University, Syracuse, New York, USA.ORCID https://orcid.org/0000-0001-6339-4279

Funding

Center for Aging and Policy Studies (CAPS) Core D: External Research Resources Support and Dissemination CoreP30AG066583 · NIA · SYRACUSE UNIVERSITY · PI WILMOTH, JANET M · 2020 to 2024
$2.1M
NIA NIH HHS P30 AG066583
6 · The paper itself

Abstract

Background and Objectives: The gold standard method for the assessment of vascular aging is carotid-femoral pulse wave velocity (cfPWV). cfPWV can be estimated from 2 commonly assessed clinical variables-age and blood pressure. This analysis uses data from the Health and Retirement Study to examine the relationship between estimated pulse wave velocity (ePWV) and mortality among 9,293 middle age and older adults. Research Design and Methods: Cox proportional hazard models were used to predict mortality occurring over a 10- to 12-year period. Controls were included for sociodemographic characteristics (age, gender, race, ethnicity, wealth, income, and education), health status (history of cardiovascular disease [CVD], diabetes, and stroke and related medication use), health behaviors (smoking, physical activity, and body mass index), and CVD-related biomarkers (systolic and diastolic blood pressure, C-reactive protein, cystatin c, hemoglobin A1c, total cholesterol, and high-density lipoprotein cholesterol). Results: By 2018, 26.19% of the weighted analytic sample were reported as deceased. In the fully specified models that control for age, age-squared, systolic and diastolic blood pressure, sociodemographic variables, health status and behaviors, and biomarkers, ePWV was associated with a greater likelihood of mortality. Discussion and Implications: An estimate of PWV derived from age and blood pressure is independently associated with an increased likelihood of death in a representative sample of middle age and older adults in the United States.

Indexed as

Cardiovascular diseaseEstimated pulse wave velocityMortalityVascular agingVascular stiffness

Identifiers

PMID36284701
PMCPMC9585457

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.