Evidence map›Paper›PMID 36284684›Full record

ArticleJournal of geriatric cardiology : JGC2022

Efficacy of vasopressin, steroid, and epinephrine protocol for in-hospital cardiac arrest resuscitation: a systematic review and meta-analysis of randomized controlled trials with trial sequential analysis.

Danish Iltaf Satti, Yan Hiu Athena Lee, Keith Sai Kit Leung, Jeremy Man Ho Hui, Thompson Ka Ming Kot, Arslan Babar, Gauranga Mahalwar, Abraham Kc Wai, Tong Liu, Leonardo Roever and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of geriatric cardiology : JGC, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 1 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 5 countries.

Danish Iltaf SattiCardiovascular Analytics Group, Hong Kong, China-UK Collaboration.
Yan Hiu Athena LeeCardiovascular Analytics Group, Hong Kong, China-UK Collaboration.
Keith Sai Kit LeungCardiovascular Analytics Group, Hong Kong, China-UK Collaboration.
Jeremy Man Ho HuiCardiovascular Analytics Group, Hong Kong, China-UK Collaboration.
Thompson Ka Ming KotDepartment of Anaesthesia and Pain Service, Princess Margaret Hospital, Lai Chi Kok, Kowloon, Hong Kong, China.
Arslan BabarDepartment of Medicine, Cleveland Clinic Foundation, Cleveland, USA.
Gauranga MahalwarDepartment of Medicine, Cleveland Clinic Foundation, Cleveland, USA.
Abraham Kc WaiAston Medical School, Faculty of Health & Life Sciences, Aston University, Birmingham, United Kingdom.
Tong LiuTianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin, China.
Leonardo RoeverDepartment of Clinical Research, Federal University of Uberlândia, Uberlândia, Brazil.
Gary TseCardiovascular Analytics Group, Hong Kong, China-UK Collaboration.
Jeffrey Shi Kai ChanCardiovascular Analytics Group, Hong Kong, China-UK Collaboration.
Cleveland Clinic · USUniversity of Hong Kong · HKAston University · GBKent and Medway Medical SchoolSecond Hospital of Tianjin Medical University · CNUniversidade Federal de Uberlândia · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo assess the effect of vasopressin, steroid and epinephrine (VSE) combination therapy on return of spontaneous circulation (ROSC) after in-hospital cardiac arrest (IHCA), and test the conclusiveness of evidence using trial sequential analysis (TSA).

methodsThe systematic search included PubMed, EMBASE, Scopus, and Cochrane Central Register of Controlled Trials. Randomized controlled trials (RCTs) that included adult patients with IHCA, with at least one group receiving combined VSE therapy were selected. Data was extracted independently by two reviewers. The main outcome of interest was ROSC. Other outcomes included survival to hospital discharge or survival to 30 and 90 days, with good neurological outcomes.

resultsWe included a total of three RCTs (

conclusionsVSE combination therapy administered in cardiopulmonary resuscitation led to improved rates of ROSC. Future trials of VSE therapy should evaluate survival to hospital discharge, neurological function and long-term survival.

Identifiers

PMID36284684
PMCPMC9548057
OpenAlexW4307495119

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.