Evidence map›Paper›PMID 36284489›Full record

ReviewJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2023

Recent advances in arterial spin labeling perfusion MRI in patients with vascular cognitive impairment.

Dan Huang, Yunlu Guo, Xiaoyu Guan, Lijun Pan, Ziyu Zhu, Zeng'ai Chen, Rick M Dijkhuizen, Marco Duering, Fang Yu, Johannes Boltze and 1 more

Abstract readReview
In one paragraph

Review in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Cerebral perfusion features linking subclinical cardiac and aortic dysfunction to vascular brain injury.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Updates on vascular dementia.Stroke and vascular neurology · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Arterial Spin Labeling: Key Concepts and Progress Towards Use as a Clinical Tool.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2024
    Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Lower cerebral blood flow predicts cognitive decline in patients with vascular cognitive impairment.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  20. Recent advances in mechanistic, therapeutic, and diagnostic research of cerebrovascular diseases: updates from brain & BrainPET 2022.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Dan HuangDepartment of Anesthesiology, Clinical Research Center, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yunlu GuoDepartment of Anesthesiology, Clinical Research Center, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xiaoyu GuanDepartment of Anesthesiology, Clinical Research Center, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Lijun PanDepartment of Radiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ziyu ZhuDepartment of Anesthesiology, Clinical Research Center, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zeng'ai ChenDepartment of Radiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Rick M DijkhuizenBiomedical MR Imaging and Spectroscopy Group, Center for Image Sciences, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands.ORCID 0000-0002-4623-4078
Marco DueringInstitute for Stroke and Dementia Research, University Hospital, LMU Munich, Germany.ORCID 0000-0003-2302-3136
Fang YuDepartment of Anesthesiology, Westchester Medical Center, New York Medical College, NY, USA.
Johannes BoltzeSchool of Life Sciences, University of Warwick, Coventry, UK.ORCID 0000-0003-3956-4164
Peiying LiDepartment of Anesthesiology, Clinical Research Center, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0002-5721-9914

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cognitive impairment (CI) is a major health concern in aging populations. It impairs patients' independent life and may progress to dementia. Vascular cognitive impairment (VCI) encompasses all cerebrovascular pathologies that contribute to cognitive impairment (CI). Moreover, the majority of CI subtypes involve various aspects of vascular dysfunction. Recent research highlights the critical role of reduced cerebral blood flow (CBF) in the progress of VCI, and the detection of altered CBF may help to detect or even predict the onset of VCI. Arterial spin labeling (ASL) is a non-invasive, non-ionizing perfusion MRI technique for assessing CBF qualitatively and quantitatively. Recent methodological advances enabling improved signal-to-noise ratio (SNR) and data acquisition have led to an increase in the use of ASL to assess CBF in VCI patients. Combined with other imaging modalities and biomarkers, ASL has great potential for identifying early VCI and guiding prediction and prevention strategies. This review focuses on recent advances in ASL-based perfusion MRI for identifying patients at high risk of VCI.

Indexed as

Cognitive DysfunctionMagnetic Resonance ImagingAgingCerebrovascular CirculationHumansPerfusionSpin LabelsSpin Labelsarterial spin labelingcerebral blood flowneuroimagingneurovascular unitperfusion MRIVascular cognitive impairmentvascular dementia

Identifiers

PMID36284489
PMCPMC9903225

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.