Evidence map›Paper›PMID 36284438›Full record

ArticleCNS neuroscience & therapeutics2023

Inhibition of the expression of rgs-3 alleviates propofol-induced decline in learning and memory in Caenorhabditis elegans.

Ayang Zhao, Hongjiang Jin, Guibo Fan, Yan Li, Chenglong Li, Qi Li, Xiaofei Ma, Tianyang Zhao, Siqi Sun, Shuai Liu and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CNS neuroscience & therapeutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Advances in drug addiction research usingFrontiers in cell and developmental biology · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Ayang ZhaoDepartment of Anesthesiology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China.
Hongjiang JinDepartment of Anesthesiology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China.
Guibo FanDepartment of Anesthesiology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China.
Yan LiDepartment of Anesthesiology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China.
Chenglong LiDepartment of Anesthesiology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China.
Qi LiDepartment of Anesthesiology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China.
Xiaofei MaDepartment of ICU, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China.
Tianyang ZhaoDepartment of Anesthesiology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China.
Siqi SunDepartment of Anesthesiology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China.
Shuai LiuDepartment of Anesthesiology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China.
Yueyue GaoDepartment of Anesthesiology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China.
Sihua QiDepartment of Anesthesiology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China.ORCID 0000-0002-8111-3837
Harbin Medical University · CN

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
NIH HHS P40 OD010440
6 · The paper itself

Abstract

backgroundExposure to anesthesia leads to extensive neurodegeneration and long-term cognitive deficits in the developing brain. Caenorhabditis elegans also shows persistent behavioral changes during development after exposure to anesthetics. Clinical and rodent studies have confirmed that altered expression of the regulators of G protein signaling (RGS) in the nervous system is a factor contributing to neurodegenerative and psychological diseases. Evidence from preclinical studies has suggested that RGS controls drug-induced plasticity, including morphine tolerance and addiction. This study aimed to observe the effect of propofol exposure in the neurodevelopmental stage on learning and memory in the L4 stage and to study whether this effect is related to changes in rgs-3 expression.

methodsCaenorhabditis elegans were exposed to propofol at the L1 stage, and learning and memory abilities were observed at the L4 stage. The expression of rgs-3 and the nuclear distribution of EGL-4 were determined to study the relevant mechanisms. Finally, RNA interference was performed on rgs-3-expressing cells after propofol exposure. Then, we observed their learning and memory abilities.

resultsPropofol time- and dose-dependently impaired the learning capacity. Propofol induced a decline in non-associative and associative long-term memory, rgs-3 upregulation, and a failure of nuclear accumulation of EGL-4/PKG in AWC neurons. Inhibition of rgs-3 could alleviate the propofol-induced changes.

conclusionInhibition of the expression of rgs-3 alleviated propofol-induced learning and memory deficits in Caenorhabditis elegans.

Indexed as

Caenorhabditis elegans ProteinsPropofolAnimalsCaenorhabditis elegansCyclic GMP-Dependent Protein KinasesLearningSignal TransductionCaenorhabditis elegans ProteinsCyclic GMP-Dependent Protein KinasesEGL-4 protein, C elegansPropofollearningmemoryneurodevelopmentpropofolregulators of G protein signaling

Identifiers

PMID36284438
PMCPMC9804065
OpenAlexW4307338435

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.