Evidence map›Paper›PMID 36284262›Full record

ArticleBiological procedures online2022

Angiotensin-converting enzyme 2 identifies immuno-hot tumors suggesting angiotensin-(1-7) as a sensitizer for chemotherapy and immunotherapy in breast cancer.

Jie Mei, Yun Cai, Rui Xu, Xinqian Yu, Xu Han, Miaomiao Weng, Lingyan Chen, Tao Ma, Tianshu Gao, Fei Gao and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological procedures online, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jie Mei *Department of Oncology, Wuxi Maternal and Child Health Hospital Affiliated to Nanjing Medical University, No. 48 Huaishu Rd, Wuxi, 214000, China.
Yun Cai *Department of Oncology, Wuxi Maternal and Child Health Hospital Affiliated to Nanjing Medical University, No. 48 Huaishu Rd, Wuxi, 214000, China.
Rui Xu *The First Clinical Medical College, Nanjing Medical University, Nanjing, 211166, China.
Xinqian Yu *Department of Physiology, Nanjing Medical University, No. 101 Longmian Av, Nanjing, 211166, China.
Xu HanJiangsu Breast Disease Center, the First Affiliated Hospital With Nanjing Medical University, No. 300 Guangzhou Rd, Nanjing, 210029, China.
Miaomiao WengJiangsu Breast Disease Center, the First Affiliated Hospital With Nanjing Medical University, No. 300 Guangzhou Rd, Nanjing, 210029, China.
Lingyan ChenDepartment of Oncology, Wuxi Maternal and Child Health Hospital Affiliated to Nanjing Medical University, No. 48 Huaishu Rd, Wuxi, 214000, China.
Tao MaDepartment of Breast Surgery, Wuxi Maternal and Child Health Hospital Affiliated to Nanjing Medical University, Wuxi, 214000, China.
Tianshu GaoWuxi Clinical Medical College, Nanjing Medical University, Wuxi, 214000, China.
Fei GaoWuxi Clinical Medical College, Nanjing Medical University, Wuxi, 214000, China.
Tiansong XiaJiangsu Breast Disease Center, the First Affiliated Hospital With Nanjing Medical University, No. 300 Guangzhou Rd, Nanjing, 210029, China. xiats@njmu.edu.cn.
Yichao ZhuDepartment of Physiology, Nanjing Medical University, No. 101 Longmian Av, Nanjing, 211166, China. zhuyichao@njmu.edu.cn.
Yan ZhangDepartment of Oncology, Wuxi Maternal and Child Health Hospital Affiliated to Nanjing Medical University, No. 48 Huaishu Rd, Wuxi, 214000, China. fuyou2007@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAngiotensin-converting enzyme 2 (ACE2) is known as a tumor suppressor and lowly expressed in most cancers. The expression pattern and role of ACE2 in breast cancer (BC) have not been deeply elucidated.

methodsA systematic pan-cancer analysis was conducted to assess the expression pattern and immunological role of ACE2 based on RNA-sequencing (RNA-seq) data downloaded from The Cancer Genome Atlas (TCGA). The correlation of ACE2 expression and immunological characteristics in the BC tumor microenvironment (TME) was evaluated. The role of ACE2 in predicting the response to therapeutic options was estimated. Moreover, the pharmacodynamic effect of angiotensin-(1-7) (Ang-1-7), the product of ACE2, on chemotherapy and immunotherapy was evaluated on the BALB/c mouse BC model. In addition, the plasma samples from BC patients receiving neoadjuvant chemotherapy were collected and subjected to the correlation analysis of the expression level of Ang-1-7 and the response to neoadjuvant chemotherapy.

resultsACE2 was lowly expressed in BC tissues compared with that in adjacent tissues. Interestingly, ACE2 was shown the highest correlation with immunomodulators, tumor-infiltrating immune cells (TIICs), cancer immunity cycles, immune checkpoints, and tumor mutation burden (TMB) in BC. In addition, a high level of ACE2 indicated a low response to endocrine therapy and a high response to chemotherapy, anti-ERBB therapy, antiangiogenic therapy and immunotherapy. In the mouse model, Ang-1-7 sensitized mouse BC to the chemotherapy and anti-PD-1 immunotherapy, which revealed its significant anti-tumor effect. Moreover, a high plasma level of Ang-1-7 was associated with a better response to neoadjuvant chemotherapy.

conclusionsACE2 identifies immuno-hot tumors in BC, and its enzymatic product Ang-1-7 sensitizes BC to the chemotherapy and immunotherapy by remodeling the TME.

Indexed as

ACE2Ang-1–7Breast cancerImmunotherapyTumor microenvironment

Identifiers

PMID36284262
PMCPMC9594906

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.