SynthesisMolecular psychiatry2022
Uncovering the genetic architecture of broad antisocial behavior through a genome-wide association study meta-analysis.
Open access · bronzeAbstract readMeta-Analysis
In one paragraph
Synthesis in Molecular psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 2 pooled it
9.9field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Genome-wide association analyses of borderline personality disorder identify 11 loci and highlight shared risk with mental and somatic disorders.Nature genetics · 2026Pooled it
- Pooled it
- Characterization of the chromosome 7 locus associated with suicidal behavior.Molecular psychiatry · 2026Article
- Adolescents at the crossroads: genetic associations between psychotic symptoms and antisocial traits.European child & adolescent psychiatry · 2026Article
- Fine mapping of PTSD GWAS reveals a role for amygdalabioRxiv : the preprint server for biology · 2026Article
- Mapping the genetic architecture of human cortical expansion and its links to neuropsychiatric disorders.bioRxiv : the preprint server for biology · 2026Article
- Gene-Environment Interplay Beyond Interactions: Psychosocial Environments Mediate Genetic Effects Underlying Externalizing-Behavior Trajectories.Clinical psychological science : a journal of the Association for Psychological Science · 2026Article
- Ancient regulatory evolution shapes individual language abilities in present-day humans.Science advances · 2026Article
- Hypothalamic subunit volumes and relations to violence and psychopathy in male offenders with or without a psychotic disorder.European archives of psychiatry and clinical neuroscience · 2026Article
- Exploring the genetic overlap between substance use disorder and educational attainment.Addiction (Abingdon, England) · 2026Article
- Ancient regulatory evolution shapes individual language abilities in present-day humans.bioRxiv : the preprint server for biology · 2026Article
- Neurology of cognition and social behavior. A narrative review of neurobiological bases and clinical aspects.Dementia & neuropsychologia · 2026Review
- Challenging the prescientific frameworks of criminal justice: neurobiology and criminolytic interventions in the legalome era.Frontiers in psychology · 2026Review
- Early ethics: Exploring moral intuition and maternal Influence in preschool children.PloS one · 2026Article
- Characterizing the Pleiotropic Architecture of Impulsivity and Its Links to Psychopathology and Neurodevelopment.The American journal of psychiatry · 2026Article
- Social-Cognitive Factors in Antisocial Behavior and School Violence: A Cross-Sectional Analysis of Greek Vocational Students.Children (Basel, Switzerland) · 2025Article
- Understanding the Etiology of Externalizing Problems in Young Children: The Roles of Callous-Unemotional Traits and Irritability.Journal of the American Academy of Child and Adolescent Psychiatry · 2025Article
- Symptoms of problematic alcohol use differ in their genetic associations with comorbid internalizing, externalizing, and neurodevelopmental psychiatric disorders.medRxiv : the preprint server for health sciences · 2025Article
- Temporal change in the prevalence and etiology of youth antisocial behavior.Journal of psychopathology and clinical science · 2025Article
- Associations of polygenic scores and developmental trajectories of externalizing behaviors.Development and psychopathology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
85 authors at 20 institutions in 12 countries.
Jorim J TielbeekCenter for Neurogenomics and Cognitive Research, Department of Complex Trait Genetics, Vrije Universiteit Amsterdam, De Boelelaan 1105, 1081 HV, Amsterdam, The Netherlands. j.j.tielbeek@vu.nl.ORCID http://orcid.org/0000-0002-6768-7359
Emil UffelmannCenter for Neurogenomics and Cognitive Research, Department of Complex Trait Genetics, Vrije Universiteit Amsterdam, De Boelelaan 1105, 1081 HV, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-0682-7880
Benjamin S WilliamsDepartment of Psychology and Neuroscience, Trinity College of Arts and Sciences, Duke University, 2020 West Main Street, Durham, NC, 27705, USA.ORCID http://orcid.org/0000-0003-3274-5317
Lucía Colodro-CondePsychiatric Genetics, Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, QLD, 4006, Australia.ORCID http://orcid.org/0000-0002-9004-364X
Éloi GagnonResearch Unit on Children's Psychosocial Maladjustment, École de psychologie, Université Laval, 2523 Allée des Bibliothèques, Quebec City, QC, G1V 0A6, Canada.ORCID http://orcid.org/0000-0002-7483-1371
Travis T MallardPsychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-3265-3001
Brandt E LevittCarolina Population Center, University of North Carolina at Chapel Hill, 123 Franklin St, Chapel Hill, NC, 27516, USA.
Philip R JansenCenter for Neurogenomics and Cognitive Research, Department of Complex Trait Genetics, Vrije Universiteit Amsterdam, De Boelelaan 1105, 1081 HV, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0003-1550-2444
Ada JohanssonDepartment of Psychology, Faculty of Arts, Psychology, and Theology, Åbo Akademi University, Tuomiokirkontori 3, FI-20500, Turku, Finland.
Hannah M SallisMRC Integrative Epidemiology Unit, University of Bristol, Oakfield Road, Bristol, BS8 2BN, UK.ORCID http://orcid.org/0000-0002-4793-6290
Giorgio PistisCenter for Psychiatric Epidemiology and Psychopathology, Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Route de Cery 25, CH-1008, Prilly, Vaud, Switzerland.ORCID http://orcid.org/0000-0002-4525-4608
Gretchen R B SaundersDepartment of Psychology, University of Minnesota, 75 E. River Road, Minneapolis, MN, 55455, USA.
Andrea G AllegriniSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, DeCrespigny Park, Denmark Hill, London, SE5 8AF, UK.ORCID http://orcid.org/0000-0003-4048-4292
Kaili RimfeldSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, DeCrespigny Park, Denmark Hill, London, SE5 8AF, UK.ORCID http://orcid.org/0000-0001-5139-065X
Bettina KonteDepartment of Psychiatry and Psychotherapy, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.ORCID http://orcid.org/0000-0001-5287-308X
Marieke KleinDepartment of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Geert Groteplein 10, 6500 HB, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0001-8784-5679
Annette M HartmannDepartment of Psychiatry and Psychotherapy, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.
Jessica E SalvatoreDepartment of Psychiatry, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ, USA.ORCID http://orcid.org/0000-0001-5504-5087
Ilja M NolteDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands.ORCID http://orcid.org/0000-0001-5047-4077
Ditte DemontisiPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, 8000, Aarhus C, Aarhus, Denmark.ORCID http://orcid.org/0000-0001-9124-2766
Anni L K MalmbergDepartment of Psychology and Logopedics, University of Helsinki, Haartmaninkatu 3, 00014, Helsinki, Finland.
S Alexandra BurtMichigan State University, East Lansing, MI, USA.
Jeanne E SavageCenter for Neurogenomics and Cognitive Research, Department of Complex Trait Genetics, Vrije Universiteit Amsterdam, De Boelelaan 1105, 1081 HV, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-2034-8341
Karen SugdenDepartment of Psychology and Neuroscience, Trinity College of Arts and Sciences, Duke University, 2020 West Main Street, Durham, NC, 27705, USA.
Richie PoultonDunedin Multidisciplinary Health and Development Research Unit, Department of Psychology, Dunedin, New Zealand.ORCID http://orcid.org/0000-0002-1052-4583
Kathleen Mullan HarrisDepartment of Sociology, University of North Carolina at Chapel Hill, CB# 3210, 201 Hamilton Hall, Chapel Hill, NC, 27599, USA.ORCID http://orcid.org/0000-0001-9757-1026
Scott VriezeDepartment of Psychology, University of Minnesota, 75 E. River Road, Minneapolis, MN, 55455, USA.ORCID http://orcid.org/0000-0003-3861-7930
Matt McGueDepartment of Psychology, University of Minnesota, 75 E. River Road, Minneapolis, MN, 55455, USA.ORCID http://orcid.org/0000-0002-5580-1433
William G IaconoDepartment of Psychology, University of Minnesota, 75 E. River Road, Minneapolis, MN, 55455, USA.ORCID http://orcid.org/0000-0002-3194-3090
Nina Roth MotaDepartment of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Geert Groteplein 10, 6500 HB, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0003-3504-759X
Jonathan MillUniversity of Exeter Medical School, University of Exeter, Exeter, UK.ORCID http://orcid.org/0000-0003-1115-3224
Joana F VianaThe Institute of Metabolism and Systems Research (IMSR), University of Birmingham, Edgbaston, Birmingham, UK.
Brittany L MitchellGenetic Epidemiology, Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, QLD, 4006, Australia.ORCID http://orcid.org/0000-0002-9050-1516
Jose J MorosoliPsychiatric Genetics, Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, QLD, 4006, Australia.ORCID http://orcid.org/0000-0003-3959-403X
Till F M AndlauerDepartment of Neurology, Technical University of Munich, 22 Ismaninger St., 81675, Munich, Germany.ORCID http://orcid.org/0000-0002-2917-5889
Isabelle Ouellet-MorinResearch Unit on Children's Psychosocial Maladjustment, École de criminologie, Université of Montreal, 3150 Rue Jean-Brillant, Montreal, QC, H3T 1N8, Canada.
Richard E TremblayResearch Unit on Children's Psychosocial Maladjustment, Département de pédiatrie et de psychologie, University of Montreal, 90 Avenue Vincent d'Indy, Montreal, QC, H2V 2S9, Canada.
Sylvana M CôtéResearch Unit on Children's Psychosocial Maladjustment, CHU Ste-Justine Research Center and Department of Social and Preventive Medicine, University of Montreal, 3175 Chemin de la Côte Ste-Catherine, Montreal, QC, H3T 1C5, Canada.
Jean-Philippe GouinDepartment of Psychology, Concordia University, 7141 Sherbrooke St. West, Montreal, QC, H4B 1R6, Canada.
Mara R BrendgenResearch Unit on Children's Psychosocial Maladjustment, Département de psychologie, Université du Québec à Montréal, CP 8888 succursale Centre-ville, Montreal, QC, H3C 3P8, Canada.
Ginette DionneResearch Unit on Children's Psychosocial Maladjustment, École de psychologie, Université Laval, 2523 Allée des Bibliothèques, Quebec City, QC, G1V 0A6, Canada.
Frank VitaroResearch Unit on Children's Psychosocial Maladjustment, CHU Sainte-Justine Research Center and University of Montreal, 3175 Chemin de la Côte Ste-Catherine, Montreal, QC, H3T 1C5, Canada.
Michelle K LuptonGenetic Epidemiology, Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, QLD, 4006, Australia.ORCID http://orcid.org/0000-0002-7274-7299
Nicholas G MartinGenetic Epidemiology, Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, QLD, 4006, Australia.ORCID http://orcid.org/0000-0003-4069-8020
COGA Consortium
Spit for Science Working Group
Enrique CastelaoCenter for Psychiatric Epidemiology and Psychopathology, Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Route de Cery 25, CH-1008, Prilly, Vaud, Switzerland.
Katri RäikkönenDepartment of Psychology and Logopedics, University of Helsinki, Haartmaninkatu 3, 00014, Helsinki, Finland.
Johan G ErikssonDepartment of General Practice and Primary Health Care, University of Helsinki, Tukholmankatu 8 B, Helsinki, Finland.
Jari LahtiDepartment of Psychology and Logopedics, University of Helsinki, Haartmaninkatu 3, 00014, Helsinki, Finland.ORCID http://orcid.org/0000-0002-4310-5297
Catharina A HartmanInterdisciplinary Center Psychopathology and Emotion Regulation (ICPE), University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands.
Albertine J OldehinkelInterdisciplinary Center Psychopathology and Emotion Regulation (ICPE), University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands.ORCID http://orcid.org/0000-0003-3925-3913
Harold SniederDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands.ORCID http://orcid.org/0000-0003-1949-2298
Hexuan LiuSchool of Criminal Justice, University of Cincinnati, 2840 Bearcat Way, Cincinnati, OH, 45221, USA.
Martin PreisigCenter for Psychiatric Epidemiology and Psychopathology, Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Route de Cery 25, CH-1008, Prilly, Vaud, Switzerland.ORCID http://orcid.org/0000-0001-5689-4259
Alyce WhippInstitute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, PO Box 4, (Yliopistonkatu 3), 00014, Helsinki, Finland.ORCID http://orcid.org/0000-0001-8376-8645
Eero VuoksimaaInstitute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, PO Box 4, (Yliopistonkatu 3), 00014, Helsinki, Finland.
Yi LuDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Nobels Väg 12A, 171 77, Stockholm, Sweden.ORCID http://orcid.org/0000-0001-9933-3654
Patrick JernDepartment of Psychology, Faculty of Arts, Psychology, and Theology, Åbo Akademi University, Tuomiokirkontori 3, FI-20500, Turku, Finland.ORCID http://orcid.org/0000-0001-9044-7604
Dan RujescuDepartment of Psychiatry and Psychotherapy, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.ORCID http://orcid.org/0000-0002-1432-313X
Ina GieglingDepartment of Psychiatry and Psychotherapy, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.
Teemu PalviainenInstitute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, PO Box 4, (Yliopistonkatu 3), 00014, Helsinki, Finland.ORCID http://orcid.org/0000-0002-7847-8384
Jaakko KaprioInstitute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, PO Box 4, (Yliopistonkatu 3), 00014, Helsinki, Finland.ORCID http://orcid.org/0000-0002-3716-2455
Kathryn Paige HardenDepartment of Psychology and Population Research Center, University of Texas at Austin, 108 E Dean Keeton Stop #A8000, Austin, TX, 78712, USA.ORCID http://orcid.org/0000-0002-1557-6737
Marcus R MunafòMRC Integrative Epidemiology Unit, University of Bristol, Oakfield Road, Bristol, BS8 2BN, UK.ORCID http://orcid.org/0000-0002-4049-993X
Geneviève Morneau-VaillancourtResearch Unit on Children's Psychosocial Maladjustment, École de psychologie, Université Laval, 2523 Allée des Bibliothèques, Quebec City, QC, G1V 0A6, Canada.
Robert PlominSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, DeCrespigny Park, Denmark Hill, London, SE5 8AF, UK.ORCID http://orcid.org/0000-0002-0756-3629
Essi VidingDivision of Psychology and Language Sciences, University College London, London, UK.
Brian B BoutwellSchool of Applied Sciences, University of Mississippi, John D. Bower School of Population Health, University of Mississippi Medical Center, 84 Dormitory Row West, University, MS, 38677, USA.
Fazil AlievDepartment of Psychology, Virginia Commonwealth University, Box 842018, 806W Franklin St, Richmond, VA, 23284, USA.ORCID http://orcid.org/0000-0001-8357-4699
Danielle M DickDepartment of Psychology, Virginia Commonwealth University, Box 842018, 806W Franklin St, Richmond, VA, 23284, USA.ORCID http://orcid.org/0000-0002-1636-893X
Arne PopmaAmsterdam UMC, VKC Psyche, Child and Adolescent Psychiatry & Psychosocial Care, Amsterdam, The Netherlands.
Stephen V FaraoneDepartment of Psychiatry, SUNY Upstate Medical University, Syracuse, NY, USA.
Anders D BørglumiPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, 8000, Aarhus C, Aarhus, Denmark.ORCID http://orcid.org/0000-0001-8627-7219
Sarah E MedlandPsychiatric Genetics, Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, QLD, 4006, Australia.ORCID http://orcid.org/0000-0003-1382-380X
Barbara FrankeDepartment of Human Genetics, Donders Institute for Brain, Cognition and Behaivour, Radboud University Medical Center, Geert Grooteplein 10, 6525 GA, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0003-4375-6572
Michel BoivinResearch Unit on Children's Psychosocial Maladjustment, École de psychologie, Université Laval, 2523 Allée des Bibliothèques, Quebec City, QC, G1V 0A6, Canada.ORCID http://orcid.org/0000-0001-8621-9844
Jean-Baptiste PingaultDepartment of Clinical, Educational and Health Psychology, University College London, London, UK.
Jeffrey C GlennonConway Institute of Biomolecular and Biomedical Sciences, School of Medicine, University College Dublin, Dublin, Ireland.
J C BarnesSchool of Criminal Justice, University of Cincinnati, 2840 Bearcat Way, Cincinnati, OH, 45221, USA.
Simon E FisherLanguage and Genetics Department, Max Planck Institute for Psycholinguistics, Wundtlaan 1, 6525 XD, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0002-3132-1996
Terrie E MoffittDepartment of Psychology and Neuroscience, Trinity College of Arts and Sciences, Duke University, 2020 West Main Street, Durham, NC, 27705, USA.
Avshalom CaspiDepartment of Psychology and Neuroscience, Trinity College of Arts and Sciences, Duke University, 2020 West Main Street, Durham, NC, 27705, USA.
Tinca J C PoldermanAmsterdam UMC, VKC Psyche, Child and Adolescent Psychiatry & Psychosocial Care, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0001-5564-301X
Danielle PosthumaCenter for Neurogenomics and Cognitive Research, Department of Complex Trait Genetics, Vrije Universiteit Amsterdam, De Boelelaan 1105, 1081 HV, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0001-7582-2365
University of Helsinki · FIResearch Unit on Children's Psychosocial Maladjustment · CAQIMR Berghofer Medical Research Institute · AUDuke University · USUniversity Medical Center Groningen · NLIndiana University – Purdue University Indianapolis · USRadboud University Nijmegen · NLState University of New York · USUniversity of Minnesota · USVrije Universiteit Amsterdam · NLWashington University in St. Louis · USÅbo Akademi University · FIMedical University of Vienna · ATPsychiatry Research Trust · GBRutgers, The State University of New Jersey · USUniversity of Bristol · GBVirginia Commonwealth University · USIcahn School of Medicine at Mount Sinai · USSUNY Upstate Medical University · USUniversity College Dublin · IE
Funding
Subject CollectionU10AA008401 · NIAAA · SUNY DOWNSTATE MEDICAL CENTER · PI JAY Arnold TISCHFIELD · 1989 to 2026
$162.7MProject 5 - Genetic architecture of alcohol use disorder using cross-trait genetic correlations and public next-generation sequencing studiesP50AA022537 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI MICHAEL F MILES · 2014 to 2026
$19.6MThe development of alcohol misuse and related problems from adolescence to early midlifeR01AA015416 · NIAAA · WASHINGTON UNIVERSITY · PI DICK, DANIELLE M, SALVATORE, JESSICA E · 2005 to 2024
$7.6MUsing the Genetic Architecture of Substance Use Disorders to Advance Gene Identification and Understanding of Pathways of RiskR01DA050721 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI DANIELLE M DICK · 2020 to 2026
$3.9MDeep Sequencing, Phenotyping, and Imputation in Large-Scale Biobanks: A Novel and Cost-Effective Framework to Identify Rare Mutations Associated with AddictionR01DA044283 · NIDA · UNIVERSITY OF MINNESOTA · PI ALBERT, FRANK WOLFGANG, VRIEZE, SCOTT IAN · 2019 to 2024
$3.2M5/7 Psychiatric Genomics Consortium: Finding actionable variationU01MH109514 · NIMH · CARDIFF UNIVERSITY · PI O'DONOVAN, MICHAEL · 2016 to 2020
$2.9MUsing genetically informed designs to understand the impact of parental divorce/separation and parental marital discord on offspring alcohol outcomesR01AA028064 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI SALVATORE, JESSICA E · 2020 to 2023
$1.3MVirginia Commonwealth University Guided Research Experiences & Applied Training (VCU GREAT) ProgramR25AA027402 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI Amy Elizabeth Adkins, DANIELLE M DICK · 2018 to 2026
$843kDevelopment of a Novel Personalized Risk Assessment for College Alcohol PreventionR34AA027347 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI WILLIAMS, CHELSEA DERLAN · 2019 to 2021
$610kDepartment of HealthMedical Research Council G1002190Medical Research Council G19/2Medical Research Council G9815508Medical Research Council MC_PC_15018Medical Research Council MC_PC_19009Medical Research Council MC_UU_00011/7Medical Research Council MR/P005918/1NIAAA NIH HHS P50 AA022537NIAAA NIH HHS R01 AA015416NIAAA NIH HHS R01 AA028064NIAAA NIH HHS R25 AA027402NIAAA NIH HHS R34 AA027347NIAAA NIH HHS U10 AA008401NIDA NIH HHS R01 DA044283NIDA NIH HHS R01 DA050721NIMH NIH HHS U01 MH109514Wellcome Trust
Abstract
Despite the substantial heritability of antisocial behavior (ASB), specific genetic variants robustly associated with the trait have not been identified. The present study by the Broad Antisocial Behavior Consortium (BroadABC) meta-analyzed data from 28 discovery samples (N = 85,359) and five independent replication samples (N = 8058) with genotypic data and broad measures of ASB. We identified the first significant genetic associations with broad ASB, involving common intronic variants in the forkhead box protein P2 (FOXP2) gene (lead SNP rs12536335, p = 6.32 × 10
Indexed as
Antisocial Personality DisorderConduct DisorderAggressionAnimalsGenome-Wide Association StudyMembrane ProteinsMiceMultifactorial InheritanceNerve Tissue ProteinsCNTNAP2 protein, mouseMembrane ProteinsNerve Tissue Proteins
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