ArticleScientific reports2022
Co-alterations of circadian clock gene transcripts in human placenta in preeclampsia.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- Cell-free DNA fragmentomics for preeclampsia risk assessment.Nature communications · 2026Article
- Time of day of induction impacts the total duration of labor.American journal of obstetrics & gynecology MFM · 2026Article
- Maternal circadian disruption during pregnancy and offspring diabetic cardiovascular disease risk.Frontiers in cell and developmental biology · 2026Review
- Interaction between time-of-day and oxytocin efficacy in mice and humans with and without gestational diabetes.Molecular metabolism · 2026Article
- Association ofInternational journal of molecular sciences · 2025Article
- Dysregulation of Circadian Markers, HAT1 and Associated Epigenetic Proteins, and the Anti-Aging Protein KLOTHO in Placenta of Pregnant Women with Chronic Venous Disease.Journal of personalized medicine · 2025Article
- Interaction between time-of-day and oxytocin efficacy in mice and humans with and without gestational diabetes.bioRxiv : the preprint server for biology · 2024Article
- Gene Regulatory Network Analysis of Decidual Stromal Cells and Natural Killer Cells.Reproductive sciences (Thousand Oaks, Calif.) · 2024Article
- MicroRNAs in the Pathogenesis of Preeclampsia-A Case-Control In Silico Analysis.Current issues in molecular biology · 2024Article
- Circadian Disruption and the Molecular Clock in Atherosclerosis and Hypertension.The Canadian journal of cardiology · 2023Review
- Exposure to unmethylated CpG oligonucleotides disrupts blood pressure circadian rhythms and placental clock gene network in pregnant rats.American journal of physiology. Heart and circulatory physiology · 2023Article
- Disruption of the Expression of the Placental Clock and Melatonin Genes in Preeclampsia.International journal of molecular sciences · 2023Article
- Placental circadian lincRNAs and spontaneous preterm birth.Frontiers in genetics · 2022Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Pre-eclampsia (PE) is a hypertensive condition that occurs during pregnancy and complicates up to 4% of pregnancies. PE exhibits several circadian-related characteristics, and the placenta possesses a functioning molecular clock. We examined the associations of 17 core circadian gene transcripts in placenta with PE vs. non-PE (a mixture of pregnant women with term, preterm, small-for-gestational-age, or chorioamnionitis) using two independent gene expression datasets: GSE75010-157 (80 PE vs. 77 non-PE) and GSE75010-173 (77 PE and 96 non-PE). We found a robust difference in circadian gene expression between PE and non-PE across the two datasets, where CRY1 mRNA increases and NR1D2 and PER3 transcripts decrease in PE placenta. Gene set variation analysis revealed an interplay between co-alterations of circadian clock genes and PE with altered hypoxia, cell migration/invasion, autophagy, and membrane trafficking pathways. Using human placental trophoblast HTR-8 cells, we show that CRY1/2 and NR1D1/2 regulate trophoblast migration. A subgroup study including only term samples demonstrated that CLOCK, NR1D2, and PER3 transcripts were simultaneously decreased in PE placenta, a finding supported by CLOCK protein downregulation in an independent cohort of human term PE placenta samples. These findings provide novel insights into the roles of the molecular clock in the pathogenesis of PE.
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