Evidence map›Paper›PMID 36284079›Full record

ReviewHeart failure reviews2023

Right ventricular failure in left heart disease: from pathophysiology to clinical manifestations and prognosis.

Frank L Dini, Nicola Riccardo Pugliese, Pietro Ameri, Umberto Attanasio, Roberto Badagliacca, Michele Correale, Valentina Mercurio, Carlo Gabriele Tocchetti, Piergiuseppe Agostoni, Alberto Palazzuoli and 1 more

Registry-linked trialOpen access · bronzeAbstract readReview
In one paragraph

Review in Heart failure reviews, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06002321 (Right Ventricular Dysfunction in Chronic Heart Failure), which is not on this map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06002321 not yet recruitingnot on this map

Right Ventricular Dysfunction in Chronic Heart Failure: Clinical Laboratory and Echocardiographic Characteristics

Typeobservational_patient_registrySponsorUniversity of SienaRan2023 to 2026Enrolled1,000ConditionsChronic Heart Failure, Right Ventricular Dysfunction, Right Heart FailureArmsEchocardiography, Laboratory Test
3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 54 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 2 countries.

Frank L DiniSant'Agostino Medical Center, Via Temperanza, 6, 20127, Milano, Italy. franklloyddini@gmail.com.ORCID http://orcid.org/0000-0003-1458-4820
Nicola Riccardo PuglieseDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Pietro AmeriDepartment of Internal Medicine, University of Genoa, Genoa, Italy.
Umberto AttanasioDepartment of Translational Medical Sciences (DISMET), Federico II University, Naples, Italy.
Roberto BadagliaccaDepartment of Cardiovascular and Respiratory Science, La Sapienza University, Rome, Italy.
Michele CorrealeDepartment of Cardiology, University Hospital Foggia, Foggia, Italy.
Valentina MercurioDepartment of Translational Medical Sciences (DISMET), Federico II University, Naples, Italy.
Carlo Gabriele TocchettiDepartment of Translational Medical Sciences (DISMET), Federico II University, Naples, Italy.
Piergiuseppe AgostoniDipartimento di Scienze Cliniche e di Comunità, Università di Milano, Milan, Italy.
Alberto PalazzuoliCardiovascular Diseases Unit, Cardio-Thoracic and Vascular Department, S. Maria Le Scotte Hospital, University of Siena, Siena, Italy.
Heart Failure Study Group of the Italian Society of Cardiology
Federico II University Hospital · ITDe Agostini (Italy) · ITOspedale Policlinico San Martino · ITSapienza University of Rome · ITUniversity of Foggia · ITUniversity of Milan · ITUniversity of Pisa · ITUniversity of Siena · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Right heart failure (RHF) is a clinical syndrome in which symptoms and signs are caused by dysfunction and/or overload of the right heart structures, predominantly the right ventricle (RV), resulting in systemic venous hypertension, peripheral oedema and finally, the impaired ability of the right heart to provide tissue perfusion. Pathogenesis of RHF includes the incompetence of the right heart to maintain systemic venous pressure sufficiently low to guarantee an optimal venous return and to preserve renal function. Virtually, all myocardial diseases involving the left heart may be responsible for RHF. This may result from coronary artery disease, hypertension, valvular heart disease, cardiomyopathies and myocarditis. The most prominent clinical signs of RHF comprise swelling of the neck veins with an elevation of jugular venous pressure and ankle oedema. As the situation worsens, fluid accumulation becomes generalised with extensive oedema of the legs, congestive hepatomegaly and eventually ascites. Diagnosis of RHF requires the presence of signs of elevated right atrial and venous pressures, including dilation of neck veins, with at least one of the following criteria: (1) compromised RV function; (2) pulmonary hypertension; (3) peripheral oedema and congestive hepatomegaly. Early recognition of RHF and identifying the underlying aetiology as well as triggering factors are crucial to treating patients and possibly reversing the clinical manifestations effectively and improving prognosis.

Indexed as

Heart FailureHypertension, PulmonaryVentricular Dysfunction, RightHeart VentriclesHepatomegalyHumansPrognosisVentricular Function, RightHeart failureOedemaPulmonary hypertensionRight ventricular dysfunctionSystemic venous pressure

Identifiers

PMID36284079
PMCPMC9596338
OpenAlexW4307844692

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.