Evidence map›Paper›PMID 36284022›Full record

ArticleEuropean journal of nutrition2023

Dietary fatty acid intake in childhood and the risk of islet autoimmunity and type 1 diabetes: the DIPP birth cohort study.

Leena Hakola, Anna-Leena Vuorinen, Hanna-Mari Takkinen, Sari Niinistö, Suvi Ahonen, Jenna Rautanen, Essi J Peltonen, Jaakko Nevalainen, Jorma Ilonen, Jorma Toppari and 3 more

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Article in European journal of nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.5field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Leena HakolaUnit of Health Sciences, Faculty of Social Sciences, Tampere University, Tampere, Finland. leena.hakola@tuni.fi.ORCID http://orcid.org/0000-0001-7115-6035
Anna-Leena VuorinenUnit of Health Sciences, Faculty of Social Sciences, Tampere University, Tampere, Finland.ORCID http://orcid.org/0000-0002-5658-1305
Hanna-Mari TakkinenUnit of Health Sciences, Faculty of Social Sciences, Tampere University, Tampere, Finland.
Sari NiinistöHealth and Well-Being Promotion Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.
Suvi AhonenUnit of Health Sciences, Faculty of Social Sciences, Tampere University, Tampere, Finland.
Jenna RautanenHealth and Well-Being Promotion Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.
Essi J PeltonenUnit of Health Sciences, Faculty of Social Sciences, Tampere University, Tampere, Finland.ORCID http://orcid.org/0000-0002-5782-3089
Jaakko NevalainenUnit of Health Sciences, Faculty of Social Sciences, Tampere University, Tampere, Finland.ORCID http://orcid.org/0000-0001-6295-0245
Jorma IlonenImmunogenetics Laboratory, Institute of Biomedicine, University of Turku, Turku, Finland.ORCID http://orcid.org/0000-0002-9973-2062
Jorma ToppariInstitute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, and Centre for Population Health Research, University of Turku, Turku, Finland.
Riitta VeijolaPEDEGO Research Unit, Department of Pediatrics, Medical Research Center, University of Oulu, Oulu, Finland.ORCID http://orcid.org/0000-0002-6557-270X
Mikael KnipPediatric Research Center, Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.ORCID http://orcid.org/0000-0003-0474-0033
Suvi M VirtanenUnit of Health Sciences, Faculty of Social Sciences, Tampere University, Tampere, Finland.ORCID http://orcid.org/0000-0001-8928-0878
Tampere University · FIFinnish Institute for Health and Welfare · FIUniversity of Turku · FIOulu University Hospital · FIUniversity of Helsinki · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe aim was to study the associations between dietary intake of fatty acids in childhood and the risk of islet autoimmunity and type 1 diabetes (T1D).

methodsThe prospective Finnish Type 1 Diabetes Prediction and Prevention (DIPP) Study included children with genetic susceptibility to T1D born between 1996 and 2004. Participants were followed up every 3 to 12 months up to 6 years for diet, islet autoantibodies, and T1D. Dietary intake of several fatty acids at the age of 3 months to 6 years was assessed 1-8 times per participant with a 3-day food record. Joint models adjusted for energy intake, sex, HLA genotype and familial diabetes were used to investigate the associations of longitudinal intake of fatty acids and the development of islet autoimmunity and T1D.

resultsDuring the 6-year follow-up, 247 (4.4%) children of 5626 developed islet autoimmunity and 94 (1.7%) children of 5674 developed T1D. Higher intake of monounsaturated fatty acids (HR 0.63; 95% CI 0.47, 0.82), arachidonic acid (0.69; 0.50, 0.94), total n-3 fatty acids (0.64; 0.48, 0.84), and long-chain n-3 fatty acids (0.14; 0.04, 0.43), was associated with a decreased risk of islet autoimmunity with and without energy adjustment. Higher intake of total fat (0.73; 0.53, 0.98), and saturated fatty acids (0.55; 0.33, 0.90) was associated with a decreased risk of T1D only when energy adjusted.

conclusionIntake of several fatty acids was associated with a decreased risk of islet autoimmunity or T1D among high-risk children. Our findings support the idea that dietary factors, including n-3 fatty acids, may play a role in the disease process of T1D.

Indexed as

Diabetes Mellitus, Type 1Fatty Acids, Omega-3Islets of LangerhansAutoantibodiesAutoimmunityChildCohort StudiesFatty AcidsHumansInfantPentamidineProspective Studies1,3-di(4-imidazolinophenoxyl)propaneAutoantibodiesFatty AcidsFatty Acids, Omega-3PentamidineAutoimmune diseasesChildren Dietary intakeCohort studyDiabetes mellitus, Type 1Fatty acids

Identifiers

PMID36284022
PMCPMC9941262
OpenAlexW4307342950

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.