ArticleInternational journal of colorectal disease2022
Lymph node metastasis in T1 colorectal cancer with the only high-risk histology of submucosal invasion depth ≥ 1000 μm.
Article in International journal of colorectal disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 21 citations in OpenAlex.
- 3-Dimensional reconstruction reveals frequent intraluminal growth of submucosal veins in surgically resected pT1 colorectal cancers.Journal of pathology and translational medicine · 2026Article
- Identification of clinical and pathological risk factors for lymph-node metastasis in T1 stage colon cancer: a population-based study.Updates in surgery · 2025Article
- Evaluation of the utility of a nomogram for predicting lymph node metastasis in T1 colorectal cancer in shared decision-making in clinical practice: a survey-based study.Annals of coloproctology · 2025Article
- Ramifications of lymph node metastasis in patients with pT1 colorectal cancer.Translational cancer research · 2025Article
- T1 Colorectal Cancer: What Are the Barriers to Minimizing Unnecessary Surgical Interventions?United European gastroenterology journal · 2025Article
- Article
- Differentiation grade as a risk factor for lymph node metastasis in T1 colorectal cancer.DEN open · 2024Article
- Comparative prediction of lymph node metastasis in pT1 colorectal cancer among Western and Japanese guidelines.Frontiers in oncology · 2024Article
- Endoscopic resection alone as a potential treatment method for low-risk deep invasive T1 colorectal cancer.iGIE : innovation, investigation and insights · 2023Article
- Endoscopic Treatment of T1 Colorectal Cancer.Cancers · 2023Review
- Difficult colorectal polypectomy: Technical tips and recent advances.World journal of gastroenterology · 2023Review
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8 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
purposeThe number of patients undergoing additional surgery after endoscopic resection (ER) for T1 colorectal cancer (CRC) is increasing. Regarding high-risk histology of lymph node metastasis (LNM) in T1 CRC, a submucosal invasion depth ≥ 1000 μm (T1b) alone may be related to a low incidence of LNM. This study was conducted to clarify the incidence of LNM and to identify factors associated with LNM in T1 CRC with high-risk histology characterized only by T1b.
methodsWe retrospectively investigated patients with pathological T1b CRC who underwent colorectal resection between 2010 and 2020. Patients were divided into two groups with high-risk histology: those in whom the only high-risk feature was T1b (low-risk T1b group, n = 263), and those with T1b as well as lymphovascular invasion, tumor budding, or poorly differentiated or mucinous adenocarcinoma (high-risk T1b group, n = 289). The incidences of LNM and recurrence were compared. Multivariate analysis was performed to identify factors associated with LNM in the low-risk T1b group.
resultsThe incidences of LNM were 3.8% and 21.6% in the Low- and High-risk T1b groups, respectively (p < 0.01), while the 5-year recurrence rates in the two groups were 0.6% and 3.4%, respectively (p = 0.10). Multivariate analysis revealed that only a predominant histological type of moderately differentiated adenocarcinoma (p = 0.04) was independently associated with LNM in the low-risk T1b group.
conclusionWhen considering the omission of additional surgery after ER in cases of T1 CRC whose only high-risk histological feature is T1b, attention should be paid to the predominant histological type.
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