Evidence map›Paper›PMID 36283759›Full record

Observational studyClinical journal of the American Society of Nephrology : CJASN2022

Toxic Occupational Exposures and Membranous Nephropathy.

Marion Cremoni, Sophie Agbekodo, Maxime Teisseyre, Kevin Zorzi, Vesna Brglez, Sylvia Benzaken, Vincent Esnault, Jo-Hanna Planchard, Barbara Seitz-Polski

Registry-linked trialOpen access · greenAbstract readObservational StudyVideo-Audio Media
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Clinical journal of the American Society of Nephrology : CJASN, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04326218 (Immunopathological Analysis in a French National Cohort of Membranous Nephropathy), which is not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04326218 narecruitingnot on this map

Immunopathological Analysis in a French National Cohort of Membranous Nephropathy (IHMN)

TypeinterventionalSponsorCentre Hospitalier Universitaire de NiceRan2020 to 2031Enrolled400ConditionsMembranous NephropathyArmsBlood sample
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Marion CremoniReference Center for Rare Diseases Idiopathic Nephrotic Syndrome, Nice University Hospital, Nice, France.ORCID 0000-0002-5837-9469
Sophie AgbekodoDepartment of Occupational Health, Cimiez Hospital, Nice University Hospital, Nice, France.
Maxime TeisseyreReference Center for Rare Diseases Idiopathic Nephrotic Syndrome, Nice University Hospital, Nice, France.
Kevin ZorziReference Center for Rare Diseases Idiopathic Nephrotic Syndrome, Nice University Hospital, Nice, France.
Vesna BrglezReference Center for Rare Diseases Idiopathic Nephrotic Syndrome, Nice University Hospital, Nice, France.
Sylvia BenzakenImmunology Laboratory, Archet 1 Hospital, Nice University Hospital, Nice, France.
Vincent EsnaultReference Center for Rare Diseases Idiopathic Nephrotic Syndrome, Nice University Hospital, Nice, France.
Jo-Hanna PlanchardDepartment of Occupational Health, Cimiez Hospital, Nice University Hospital, Nice, France.
Barbara Seitz-PolskiReference Center for Rare Diseases Idiopathic Nephrotic Syndrome, Nice University Hospital, Nice, France seitz-polski.b@chu-nice.fr.
Hôpital Pasteur · FRInstitut de Chimie de Nice · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesMembranous nephropathy is a rare autoimmune kidney disease whose increasing prevalence in industrialized countries pleads for the involvement of an environmental factor in the development of the disease. In addition, the predominance of men in membranous nephropathy, classically attributed to biologic or genetic differences between men and women, could also be due to different occupational exposures. To support this hypothesis, we sought to describe the toxic occupational exposures of patients with membranous nephropathy. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: In this observational epidemiologic study, we compared the occupations and toxic occupational exposures of 100 patients with membranous nephropathy with those of the general population, consisting of two cohorts of 26,734,000 and 26,500 French workers. We then compared the characteristics of patients exposed to an occupational toxic substance with those of unexposed patients.

resultsPatients with membranous nephropathy worked more frequently in the construction sector than the general population (33% versus 7%,

conclusionsPatients with membranous nephropathy were more frequently exposed to certain occupational toxic substances, such as asbestos and organic solvents, than the general population. This occupational exposure was more frequent in men and in patients with PLA2R1 epitope spreading. CLINICAL TRIAL REGISTRY NAME AND REGISTRATION NUMBER: Immunopathological Analysis in a French National Cohort of Membranous Nephropathy (IHMN), NCT04326218. PODCAST: This article contains a podcast at https://www.asn-online.org/media/podcast/CJASN/2022_10_25_CJN02930322.mp3.

Indexed as

AsbestosGlomerulonephritis, MembranousOccupational ExposureAutoantibodiesEpitopesFemaleHumansMaleReceptors, Phospholipase A2SolventsAsbestosAutoantibodiesEpitopesPLA2R1 protein, humanReceptors, Phospholipase A2Solventsmembranous nephropathynephrotic syndromeoccupational exposure

Identifiers

PMID36283759
PMCPMC9718038
OpenAlexW4307340012

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.