ArticleRMD open2022
Worse long-term renal outcome of lupus nephritis patients of African descent living in Europe.
Article in RMD open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 5 citations in OpenAlex.
- Repeat biopsies in membranous lupus nephritis in the era of target antigen identification.Virchows Archiv : an international journal of pathology · 2025Article
- Remission of lupus nephritis: the trajectory of histological response in successfully treated patients.Lupus science & medicine · 2023Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
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Abstract
introductionPrognosis of lupus nephritis (LN) among patients of African descent living in Europe has been understudied.
methodsIn a retrospective study performed in two European university hospitals, we compared the prognosis of LN in patients of African descent or Caucasians. Remission was defined as a urine protein to creatinine (uP/C) ratio<0.5 g/g and a serum creatinine value<120% of baseline. Renal relapse was defined as the reappearance of a uP/C>1 g/g, leading to a repeat kidney biopsy and/or immunosuppressive treatment change. Chronic kidney disease (CKD) was defined as estimated glomerular filtration rate≤60 mL/min/1.73 m
results52 patients of African descent and 85 Caucasian patients were included in this analysis. Class III and isolated class V LN were more common among patients of African descent. Time to first renal remission did not differ between ethnic subgroups. By contrast, patients of African descent suffered from earlier renal flares, CKD was more common and time to CKD was shorter after a flare. In a multivariate analysis, African ancestry was an independent risk factor for progression to CKD. We observed no significant difference in non-adherence to treatment between the two groups.
conclusionLN patients of African descent have worse renal outcomes, mainly explained by a higher rate of renal flare.
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