Evidence map›Paper›PMID 36283704›Full record

ArticleLife science alliance2023

Stepwise progression of β-selection during T cell development involves histone deacetylation.

Anchi S Chann, Mirren Charnley, Lucas M Newton, Andrea Newbold, Florian Wiede, Tony Tiganis, Patrick O Humbert, Ricky W Johnstone, Sarah M Russell

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life science alliance, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Anchi S ChannOptical Sciences Centre, School of Science, Swinburne University of Technology, Hawthorn, Australia.ORCID 0000-0002-8778-5327
Mirren CharnleyOptical Sciences Centre, School of Science, Swinburne University of Technology, Hawthorn, Australia.ORCID 0000-0003-3845-9290
Lucas M NewtonDepartment of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Australia.ORCID 0000-0001-5984-5778
Andrea NewboldPeter MacCallum Cancer Centre, Melbourne, Australia.ORCID 0000-0002-0481-2431
Florian WiedeMonash Biomedicine Discovery Institute, Monash University, Clayton, Australia.ORCID 0000-0001-5145-7180
Tony TiganisMonash Biomedicine Discovery Institute, Monash University, Clayton, Australia.ORCID 0000-0002-8065-9942
Patrick O HumbertDepartment of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Australia.ORCID 0000-0002-1366-6691
Ricky W JohnstonePeter MacCallum Cancer Centre, Melbourne, Australia.ORCID 0000-0001-7053-9237
Sarah M RussellOptical Sciences Centre, School of Science, Swinburne University of Technology, Hawthorn, Australia sarah.russell@petermac.org.ORCID 0000-0001-5826-9641
The University of Melbourne · AUAustralian Regenerative Medicine Institute · AUPeter MacCallum Cancer Centre · AULa Trobe University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

During T cell development, the first step in creating a unique T cell receptor (TCR) is genetic recombination of the TCRβ chain. The quality of the new TCRβ is assessed at the β-selection checkpoint. Most cells fail this checkpoint and die, but the coordination of fate at the β-selection checkpoint is not yet understood. We shed new light on fate determination during β-selection using a selective inhibitor of histone deacetylase 6, ACY1215. ACY1215 disrupted the β-selection checkpoint. Characterising the basis for this disruption revealed a new, pivotal stage in β-selection, bookended by up-regulation of TCR co-receptors, CD28 and CD2, respectively. Within this "DN3b

Indexed as

CD28 AntigensReceptors, Antigen, T-Cell, alpha-betaHistone Deacetylase 6HistonesReceptors, Antigen, T-CellT-LymphocytesCD28 AntigensHistone Deacetylase 6HistonesReceptors, Antigen, T-CellReceptors, Antigen, T-Cell, alpha-beta

Identifiers

PMID36283704
PMCPMC9595210
OpenAlexW4307502601

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.