Evidence map›Paper›PMID 36283322›Full record

ArticleMultiple sclerosis and related disorders2022

Impact of resilience, social support, and personality traits in patients with neuroinflammatory diseases during the COVID-19 pandemic.

Dejan Jakimovski, Katelyn S Kavak, Erin E Longbrake, Elle Levit, Christopher M Perrone, Amit Bar-Or, Ralph Hb Benedict, Claire S Riley, Philip L De Jager, Shruthi Venkatesh and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Multiple sclerosis and related disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 1 country.

Dejan JakimovskiBuffalo Neuroimaging Analysis Center, Department of Neurology, University at Buffalo, State University of New York, Buffalo, NY, United States; Department of Neurology, Jacobs School of Medicine and Biomedical Science Center, University of Buffalo, State University of New York, 1010 Main Street, Buffalo, NY 14202, United States.
Katelyn S KavakDepartment of Neurology, Jacobs School of Medicine and Biomedical Science Center, University of Buffalo, State University of New York, 1010 Main Street, Buffalo, NY 14202, United States.
Erin E LongbrakeDepartment of Neurology, Yale University, New Haven, CT, United States.
Elle LevitDepartment of Neurology, Yale University, New Haven, CT, United States.
Christopher M PerroneCenter for Neuroinflammation and Experimental Therapeutics and Division of MS and Related Disorders, University of Pennsylvania, Philadelphia, PA, United States.
Amit Bar-OrCenter for Neuroinflammation and Experimental Therapeutics and Division of MS and Related Disorders, University of Pennsylvania, Philadelphia, PA, United States.
Ralph Hb BenedictDepartment of Neurology, Jacobs School of Medicine and Biomedical Science Center, University of Buffalo, State University of New York, 1010 Main Street, Buffalo, NY 14202, United States.
Claire S RileyCenter for Translational & Computational Neuroimmunology, Department of Neurology, Columbia Multiple Sclerosis Center, New York NY, United States.
Philip L De JagerCenter for Translational & Computational Neuroimmunology, Department of Neurology, Columbia Multiple Sclerosis Center, New York NY, United States.
Shruthi VenkateshDepartment of Neurology, University of Pittsburgh, Pittsburgh PA, United States.
Elizabeth L S WalkerDepartment of Neurology, University of Pittsburgh, Pittsburgh PA, United States.
Zongqi XiaDepartment of Neurology, University of Pittsburgh, Pittsburgh PA, United States.
Bianca Weinstock-GuttmanDepartment of Neurology, Jacobs School of Medicine and Biomedical Science Center, University of Buffalo, State University of New York, 1010 Main Street, Buffalo, NY 14202, United States. Electronic address: bw8@buffalo.edu.
Multiple Sclerosis Resilience to COVID-19 (MSReCOV) Collaborative
University at Buffalo, State University of New York · USUniversity of Pittsburgh · USMultiple Sclerosis Center Of Northeastern New York · USUniversity of Pennsylvania · USYale University · USBuffalo Psychiatric Center · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Real-world impact of the COVID-19 pandemic in people with multiple sclerosisR01NS124882 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI XIA, ZONGQI · 2022 to 2024
$1.2M
Interactions between Gut Microbiome and B-Cell Depletion in Multiple SclerosisK23NS107624 · NINDS · YALE UNIVERSITY · PI LONGBRAKE, ERIN · 2019 to 2023
$980k
6 · The paper itself

Abstract

BACKGROUND AND

objectiveThe COVID-19 pandemic negatively impacted the well-being of persons with neuroinflammatory diseases (pwNID). Identifying factors that influence the response to challenging conditions could guide supportive care.

methods2185 pwNID and 1079 healthy controls (HCs) from five US centers completed an online survey regarding the effects of the COVID-19 pandemic on physical and psychological well-being. Survey instruments included resilience (Connor-Davidson Resilience Scale, CD-RISC), loneliness (UCLA Loneliness Scale), social support (modified social support survey, MSSS-5), personality traits (NEO-Five Factor Inventory, NEO-FFI), and disability (Patient-Determined Disability Steps (PDDS). Step-wise regression models and mediation analyses assessed whether the level of self-reported resilience, size of the social support, and specific personality traits (study predictors) were associated with self-reported disability and/or loneliness (study outcomes).

resultsThe response rate varied significantly between the questionnaires. While, all pwNID completed the demographic questionnaire, 78.8% completed the loneliness questionnaire and 49.7% completed the NEO-FFI. Based on 787 responses, greater neuroticism (standardized β = 0.312, p < 0.001), less social support (standardized β = -0.242, p < 0.001), lower extraversion (standardized β = -0.083, p=0.017), lower agreeableness (standardized β = -0.119, p < 0.001), and lower resilience (standardized β = -0.125, p = 0.002) were associated with the feeling of loneliness. Social support and resilience modestly but significantly mediated the association between personality traits and loneliness. Older age (standardized β = 0.165, p < 0.001) and lower conscientiousness (standardized β = -0.094, p = 0.007) were associated with worse disability (higher PDDS scores). There were no differences in outcomes between pwNID and HCs.

conclusionGreater social support potentially attenuates the association between neuroticism and the feeling of loneliness in pwNID during the COVID-19 pandemic. Assessment of personality traits may identify pwNID that are in greater need of social support and guide targeted interventions.

Indexed as

COVID-19PersonalityHumansNeuroinflammatory DiseasesPandemicsSocial SupportLonelinessNeuroticismPatient-reported outcomesPersonalityResilience

Identifiers

PMID36283322
PMCPMC9548342
OpenAlexW4303940586

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.