Evidence map›Paper›PMID 36283250›Full record

ReviewBioorganic & medicinal chemistry2022

Development of carbohydrate based next-generation anti-pertussis vaccines.

Peng Wang, Sherif Ramadan, Purnima Dubey, Rajendar Deora, Xuefei Huang

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Bioorganic & medicinal chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Peng WangDepartment of Chemistry, Michigan State University, 578 S. Shaw Lane, East Lansing, MI 48824, USA.
Sherif RamadanDepartment of Chemistry, Michigan State University, 578 S. Shaw Lane, East Lansing, MI 48824, USA; Chemistry Department, Faculty of Science, Benha University, Benha, Qaliobiya 13518, Egypt.
Purnima DubeyDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus, OH 43210, USA.
Rajendar DeoraDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus, OH 43210, USA; Department of Microbiology, The Ohio State University, Columbus, OH 43210, USA.
Xuefei HuangDepartment of Chemistry, Michigan State University, 578 S. Shaw Lane, East Lansing, MI 48824, USA; Institute for Quantitative Health Science and Engineering, East Lansing, MI 48824, USA; Department of Biomedical Engineering, Michigan State University, East Lansing, MI 48824, USA. Electronic address: huangxu2@msu.edu.
Michigan State University · USThe Ohio State University · US

Funding

Identification of novel immunogenic proteins from Bordetella pertussisR01AI153829 · NIAID · OHIO STATE UNIVERSITY · PI DEORA, RAJENDAR K, DUBEY, PURNIMA · 2021 to 2025
$3.8M
Synthetic glycan conjugates with bacteriophage Qbeta for broad spectrum anti-salmonella vaccinesR01AI146210 · NIAID · MICHIGAN STATE UNIVERSITY · PI HUANG, XUEFEI · 2019 to 2023
$1.5M
Bordetella cell surface modification and pathogenesisR21AI156732 · NIAID · OHIO STATE UNIVERSITY · PI DEORA, RAJENDAR K · 2021 to 2022
$454k
NIAID NIH HHS R01 AI146210NIAID NIH HHS R01 AI153829NIAID NIH HHS R21 AI156732
6 · The paper itself

Abstract

Pertussis is a highly contagious respiratory disease caused by the Gram-negative bacterial pathogen, Bordetella pertussis. Despite high global vaccination rates, pertussis is resurging worldwide. Here we discuss the development of current pertussis vaccines and their limitations, which highlight the need for new vaccines that can protect against the disease and prevent development of the carrier state, thereby reducing transmission. The lipo-oligosaccharide of Bp is an attractive antigen for vaccine development as the anti-glycan antibodies could have bactericidal activities. The structure of the lipo-oligosaccharide has been determined and its immunological properties analyzed. Strategies enabling the expression, isolation, and bioconjugation have been presented. However, obtaining the saccharide on a large scale with high purity remains one of the main obstacles. Chemical synthesis provides a complementary approach to accessing the carbohydrate epitopes in a pure and structurally well-defined form. The first total synthesis of the non-reducing end pertussis pentasaccharide is discussed. The conjugate of the synthetic glycan with a powerful immunogenic carrier, bacteriophage Qβ, results in high levels and long-lasting anti-glycan IgG antibodies, paving the way for the development of a new generation of anti-pertussis vaccines with high bactericidal activities and biocompatibilities.

Indexed as

Antibodies, BacterialWhooping CoughBordetella pertussisHumansOligosaccharidesPertussis VaccineAntibodies, BacterialOligosaccharidesPertussis VaccineBordetella PertussisLipo-oligosaccharideSynthesisVaccines

Identifiers

PMID36283250
PMCPMC9925305
OpenAlexW4306405276

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.