Evidence map›Paper›PMID 36283187›Full record

ArticleDrug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy2022

Dual use of antifungals in medicine and agriculture: How do we help prevent resistance developing in human pathogens?

Paul E Verweij, Maiken C Arendrup, Ana Alastruey-Izquierdo, Jeremy A W Gold, Shawn R Lockhart, Tom Chiller, P Lewis White

Open access · hybridAbstract read
In one paragraph

Article in Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.

  1. Azole resistance inFrontiers in veterinary science · 2025
    Pooled it
  2. Review
  3. Review
  4. Thermal adaptation crosstalk with azole response through lncRNA inbioRxiv : the preprint server for biology · 2026
    Article
  5. Article
  6. Characteristics of individualAntimicrobial agents and chemotherapy · 2026
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Global, Regional, and National Burden of Pulmonary Fungal Infections 1990-2021.American journal of respiratory and critical care medicine · 2025
    Article
  14. Article
  15. Article
  16. Doubling of triazole resistance rates in invasive aspergillosis over a 10-year period, Belgium, 1 April 2022 to 31 March 2023.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2025
    Article
  17. Refractory versus resistant invasive aspergillosis.The Journal of antimicrobial chemotherapy · 2025
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 5 countries.

Paul E VerweijDepartment of Medical Microbiology and Radboudumc-CWZ Center of Expertise for Mycology, Radboud University Medical Center, Nijmegen, the Netherlands; Centre for Infectious Diseases Research, Diagnostics and Laboratory Surveillance, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands. Electronic address: Paul.verweij@radboudumc.nl.
Maiken C ArendrupUnit for Mycology, Statens Serum Insitut, Copenhagen, Denmark; Department of Medical Microbiology, University Hospital Rigshospitalet, Copenhagen, Denmark; Department of Clinical Medicine, Copenhagen University, Copenhagen, Denmark.
Ana Alastruey-IzquierdoMycology Reference Laboratory, Instituto de Salud Carlos III, Madrid, Spain.
Jeremy A W GoldMycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, USA.
Shawn R LockhartMycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, USA.
Tom ChillerMycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, USA.
P Lewis WhitePublic Health Wales Mycology Reference Laboratory, Cardiff, United Kingdom.
Centers for Disease Control and Prevention · USInstituto de Salud Carlos III · ESPublic Health Wales · GBRadboud University Nijmegen · NLRigshospitalet · DK

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

Azole resistance in Aspergillus fumigatus is a One Health resistance threat, where azole fungicide exposure compromises the efficacy of medical azoles. The use of the recently authorized fungicide ipflufenoquin, which shares its mode-of-action with a new antifungal olorofim, underscores the need for risk assessment for dual use of antifungals.

Indexed as

Antifungal AgentsFungicides, IndustrialAgricultureAspergillus fumigatusAzolesDrug Resistance, FungalHumansMicrobial Sensitivity TestsAntifungal AgentsAzolesFungicides, IndustrialAspergillus fumigatusDHODH inhibitorolorofimOne Healthtriazole resistance

Identifiers

PMID36283187
PMCPMC10693676
OpenAlexW4306954618

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.