Evidence map›Paper›PMID 36283180›Full record

ArticleEuropean journal of medicinal chemistry2022

From dopamine 4 to sigma 1: Synthesis, SAR and biological characterization of a piperidine scaffold of σ1 modulators.

Kirsten T Tolentino, Viktoriya Mashinson, Manish K Sharma, Yashpal S Chhonker, Daryl J Murry, Corey R Hopkins

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of medicinal chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kirsten T TolentinoDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE, 68198-6125, USA.
Viktoriya MashinsonDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE, 68198-6125, USA.
Manish K SharmaDepartment of Pharmacy Practice and Science, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE, 68198-6125, USA.
Yashpal S ChhonkerDepartment of Pharmacy Practice and Science, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE, 68198-6125, USA.
Daryl J MurryDepartment of Pharmacy Practice and Science, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE, 68198-6125, USA.
Corey R HopkinsDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE, 68198-6125, USA; UNMC Center for Drug Discovery, University of Nebraska Medical Center, Omaha, NE, 68198, USA. Electronic address: corey.hopkins@unmc.edu.

Funding

Discovery and characterization of selective D4R antagonists and their evaluation in preclinical models of PD-LIDsR01NS119266 · NINDS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI HOPKINS, COREY R. · 2021 to 2025
$2.3M
NINDS NIH HHS R01 NS119266
6 · The paper itself

Abstract

The sigma 1 receptor is a multifunctional receptor with wide distribution in the nervous system and its function has been implicated with a number of neurological disorders including dementia and Alzheimer's disease (AD) and other neurodegenerative disorders. In addition, modulators of σ1 have been advanced into clinical trials for the treatment of pain. Starting from our previously disclosed piperidine scaffold, we have identified a class of potent sigma 1 modulators. This work highlights the key SAR components that lead to the divergence in D

Indexed as

Alzheimer DiseaseReceptors, sigmaAnimalsDopamineLigandsPainPiperidinesDopamineLigandsPiperidinesReceptors, sigmaDopamine 4 receptorModulatorsSARSelectivitySigma 1 receptor

Identifiers

PMID36283180
PMCPMC12969314

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.