Evidence map›Paper›PMID 36283111›Full record

ReviewRadiology2022

Molecular Characterization and Therapeutic Approaches to Small Cell Lung Cancer: Imaging Implications.

Hyesun Park, Shu-Chi Tseng, Lynette M Sholl, Hiroto Hatabu, Mark M Awad, Mizuki Nishino

Open access · greenAbstract readReview
In one paragraph

Review in Radiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

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  8. Biological clock regulation by theFrontiers in cell and developmental biology · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Hyesun ParkFrom the Departments of Radiology (H.P., S.C.T., H.H., M.N.), Pathology (L.M.S.), Medical Oncology (M.M.A.), and Medicine (M.M.A.), Dana-Farber Cancer Institute and Brigham and Women's Hospital, 450 Brookline Ave, Boston, MA 02215.ORCID 0000-0003-0707-1875
Shu-Chi TsengFrom the Departments of Radiology (H.P., S.C.T., H.H., M.N.), Pathology (L.M.S.), Medical Oncology (M.M.A.), and Medicine (M.M.A.), Dana-Farber Cancer Institute and Brigham and Women's Hospital, 450 Brookline Ave, Boston, MA 02215.ORCID 0000-0002-9671-9006
Lynette M ShollFrom the Departments of Radiology (H.P., S.C.T., H.H., M.N.), Pathology (L.M.S.), Medical Oncology (M.M.A.), and Medicine (M.M.A.), Dana-Farber Cancer Institute and Brigham and Women's Hospital, 450 Brookline Ave, Boston, MA 02215.ORCID 0000-0002-9532-9735
Hiroto HatabuFrom the Departments of Radiology (H.P., S.C.T., H.H., M.N.), Pathology (L.M.S.), Medical Oncology (M.M.A.), and Medicine (M.M.A.), Dana-Farber Cancer Institute and Brigham and Women's Hospital, 450 Brookline Ave, Boston, MA 02215.ORCID 0000-0003-1436-2988
Mark M AwadFrom the Departments of Radiology (H.P., S.C.T., H.H., M.N.), Pathology (L.M.S.), Medical Oncology (M.M.A.), and Medicine (M.M.A.), Dana-Farber Cancer Institute and Brigham and Women's Hospital, 450 Brookline Ave, Boston, MA 02215.ORCID 0000-0003-0928-5244
Mizuki NishinoFrom the Departments of Radiology (H.P., S.C.T., H.H., M.N.), Pathology (L.M.S.), Medical Oncology (M.M.A.), and Medicine (M.M.A.), Dana-Farber Cancer Institute and Brigham and Women's Hospital, 450 Brookline Ave, Boston, MA 02215.ORCID 0000-0003-0275-0502
Dana-Farber Brigham Cancer Center · US

Funding

The Boston Lung Cancer Survival CohortU01CA209414 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI David C Christiani · 2017 to 2026
$12.2M
Automated in vivo analysis of tumor growth rate as a guide for therapeutic decisions to advance personalized cancer treatmentR01CA203636 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI NISHINO, MIZUKI · 2017 to 2021
$2.9M
NCI NIH HHS R01 CA203636NCI NIH HHS U01 CA209414
6 · The paper itself

Abstract

Small cell lung cancer (SCLC) is a highly aggressive malignancy with exceptionally poor prognosis, comprising approximately 15% of lung cancers. Emerging knowledge of the molecular and genomic landscape of SCLC and recent successful clinical applications of new systemic agents have allowed for precision oncology treatment approaches. Imaging is essential for the diagnosis, staging, and treatment monitoring of patients with SCLC. The role of imaging is increasing with the approval of new treatment agents, including immune checkpoint inhibitors, which lead to novel imaging manifestations of response and toxicities. The purpose of this state-of-the-art review is to provide the reader with the latest information about SCLC, focusing on the subtyping of this malignancy (molecular characterization) and the emerging systemic therapeutic approaches and their implications for imaging. The review will also discuss the future directions of SCLC imaging, radiomics and machine learning.

Indexed as

Lung NeoplasmsSmall Cell Lung CarcinomaHumansImmunotherapyPrecision Medicine

Identifiers

PMID36283111
PMCPMC9713457
OpenAlexW4307342668

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.