Evidence map›Paper›PMID 36283035›Full record

ArticleACS chemical neuroscience2022

Alzheimer's Disease Prevention through Natural Compounds: Cell-Free

Alessandro Palmioli, Valeria Mazzoni, Ada De Luigi, Chiara Bruzzone, Gessica Sala, Laura Colombo, Chiara Bazzini, Chiara Paola Zoia, Mariagiovanna Inserra, Mario Salmona and 4 more

Abstract read
In one paragraph

Article in ACS chemical neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Plants (Basel, Switzerland) · 2026
    Review
  3. Tau catalyzes amyloid-β aggregation and toxicity in a polymorph-dependent manner.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Alessandro PalmioliDepartment of Biotechnology and Biosciences, University of Milano-Bicocca, P.zza della Scienza 2, 20126 Milan, Italy.
Valeria MazzoniDepartment of Biotechnology and Biosciences, University of Milano-Bicocca, P.zza della Scienza 2, 20126 Milan, Italy.
Ada De LuigiDepartment of Molecular Biochemistry and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via M. Negri 2, 20156 Milano, Italy.
Chiara BruzzoneDepartment of Biotechnology and Biosciences, University of Milano-Bicocca, P.zza della Scienza 2, 20126 Milan, Italy.ORCID 0000-0003-4252-8180
Gessica SalaNeuroMI, Milan Center for Neuroscience, University of Milano-Bicocca, 20126 Milano, Italy.
Laura ColomboDepartment of Molecular Biochemistry and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via M. Negri 2, 20156 Milano, Italy.
Chiara BazziniNeuroMI, Milan Center for Neuroscience, University of Milano-Bicocca, 20126 Milano, Italy.
Chiara Paola ZoiaNeuroMI, Milan Center for Neuroscience, University of Milano-Bicocca, 20126 Milano, Italy.
Mariagiovanna InserraDepartment of Molecular Biochemistry and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via M. Negri 2, 20156 Milano, Italy.
Mario SalmonaNeuroMI, Milan Center for Neuroscience, University of Milano-Bicocca, 20126 Milano, Italy.ORCID 0000-0002-9098-9873
Ivano De NoniDepartment of Food, Environmental and Nutritional Sciences, University of Milano, Via Celoria 2, 20133 Milano, Italy.
Carlo FerrareseNeuroMI, Milan Center for Neuroscience, University of Milano-Bicocca, 20126 Milano, Italy.
Luisa DiomedeDepartment of Molecular Biochemistry and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via M. Negri 2, 20156 Milano, Italy.ORCID 0000-0002-2258-0531
Cristina AiroldiDepartment of Biotechnology and Biosciences, University of Milano-Bicocca, P.zza della Scienza 2, 20126 Milan, Italy.ORCID 0000-0002-3670-6262

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The relevant social and economic costs associated with aging and neurodegenerative diseases, particularly Alzheimer's disease (AD), entail considerable efforts to develop effective preventive and therapeutic strategies. The search for natural compounds, whose intake through diet can help prevent the main biochemical mechanisms responsible for AD onset, led us to screen hops, one of the main ingredients of beer. To explore the chemical variability of hops, we characterized four hop varieties,

Indexed as

Alzheimer DiseaseHumulusNeuroblastomaAntioxidantsBeerHumansAntioxidantsAlzheimer’s diseaseanti-Aβ compoundsCaenorhabditis eleganshopNMRUPLC-HR-MS

Identifiers

PMID36283035
PMCPMC9673154

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.