Evidence map›Paper›PMID 36283001›Full record

ArticleMultimodal learning for clinical decision support : 11th International Workshop, ML-CDS 2021, held in conjunction with MICCAI 2021, Strasbourg, France, October 1, 2021, Proceedings. ML-CDS (Workshop) (11th : 2021 : Online)2021

From Picoscale Pathology to Decascale Disease: Image Registration with a Scattering Transform and Varifolds for Manipulating Multiscale Data.

Kaitlin M Stouffer, Zhenzhen Wang, Eileen Xu, Karl Lee, Paige Lee, Michael I Miller, Daniel J Tward

Abstract read
In one paragraph

Article in Multimodal learning for clinical decision support : 11th International Workshop, ML-CDS 2021, held in conjunction with MICCAI 2021, Strasbourg, France, October 1, 2021, Proceedings. ML-CDS (Workshop) (11th : 2021 : Online), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kaitlin M StoufferJohns Hopkins University, Baltimore, MD 21218, USA.ORCID 0000-0003-4547-8836
Zhenzhen WangJohns Hopkins University, Baltimore, MD 21218, USA.
Eileen XuJohns Hopkins University, Baltimore, MD 21218, USA.
Karl LeeJohns Hopkins University, Baltimore, MD 21218, USA.
Paige LeeUniversity of California Los Angeles, Los Angeles, CA 90095, USA.
Michael I MillerJohns Hopkins University, Baltimore, MD 21218, USA.
Daniel J TwardUniversity of California Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0002-4607-6807

Funding

Project 2 MeasurementU19AG033655 · NIA · JOHNS HOPKINS UNIVERSITY · PI Abhay Moghekar · 2014 to 2026
$51.5M
Research Education ComponentP30AG066507 · NIA · JOHNS HOPKINS UNIVERSITY · PI Corinne Pettigrew · 2020 to 2026
$29.3M
Medical Scientist Training ProgramT32GM136577 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI ANDREA L COX · 2020 to 2026
$13.4M
Neurodegenerative and Neurodevelopmental Subcortical Shape DiffeomorphometryR01EB020062 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI MILLER, MICHAEL I, MOSTOFSKY, STEWART H · 2016 to 2019
$2.8M
NIA NIH HHS P30 AG066507NIA NIH HHS U19 AG033655NIBIB NIH HHS R01 EB020062NIGMS NIH HHS T32 GM136577
6 · The paper itself

Abstract

Advances in neuroimaging have yielded extensive variety in the scale and type of data available. Effective integration of such data promises deeper understanding of anatomy and disease-with consequences for both diagnosis and treatment. Often catered to particular datatypes or scales, current computational tools and mathematical frameworks remain inadequate for simultaneously registering these multiple modes of "images" and statistically analyzing the ensuing menagerie of data. Here, we present (1) a registration algorithm using a "scattering transform" to align high and low resolution images and (2) a varifold-based modeling framework to compute 3D spatial statistics of multiscale data. We use our methods to quantify microscopic tau pathology across macroscopic 3D regions of the medial temporal lobe to address a major challenge in the diagnosis of Alzheimer's Disease-the reliance on invasive methods to detect microscopic pathology.

Indexed as

Alzheimer’s diseaseScattering transformVarifold

Identifiers

PMID36283001
PMCPMC9582035

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.