Evidence map›Paper›PMID 36282988›Full record

Trial reportThe American journal of drug and alcohol abuse2023

Baseline C-reactive protein levels are predictive of treatment response to a neuroimmune modulator in individuals with an alcohol use disorder: a preliminary study.

Erica N Grodin, Lindsay R Meredith, Elizabeth M Burnette, Karen Miotto, Michael R Irwin, Lara A Ray

Open access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in The American journal of drug and alcohol abuse, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Review
  6. Review
  7. Article
  8. Early life stress is associated with greater negative emotionality and peripheral inflammation in alcohol use disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Article
  9. Novel medications for problematic alcohol use.The Journal of clinical investigation · 2024
    Review
  10. Review
  11. Article
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Erica N GrodinDepartment of Psychology, University of California at Los Angeles, Los Angeles, CA, USA.ORCID 0000-0001-5528-4918
Lindsay R MeredithDepartment of Psychology, University of California at Los Angeles, Los Angeles, CA, USA.ORCID 0000-0001-7584-9488
Elizabeth M BurnetteDepartment of Psychology, University of California at Los Angeles, Los Angeles, CA, USA.ORCID 0000-0003-4005-5885
Karen MiottoDepartment of Psychiatry and Biobehavioral Sciences, University of California at Los Angeles, Los Angeles, CA, USA.ORCID 0000-0003-0252-6383
Michael R IrwinDepartment of Psychology, University of California at Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-1502-8431
Lara A RayDepartment of Psychology, University of California at Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-5734-9444
University of California, Los Angeles · US

Funding

The Role of Striosome Neurons in Mediating Opiod RewardP50DA005010 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WALWYN, WENDY M · 1987 to 2021
$30.7M
UCLA Training Program in Translational Neuroscience of Drug Abuse (TNDA)T32DA024635 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LARA A. RAY, Kate M Wassum · 2008 to 2026
$6.2M
Clinical Neuroscience of Alcoholism: Integrating Neuroscience and Clinical TrialsK24AA025704 · NIAAA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LARA A. RAY · 2018 to 2026
$1.3M
Elucidating the Effects of Neuroimmune Modulation on Neural Substrates of Alcohol Cue and Stress ReactivityF32AA027699 · NIAAA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GRODIN, ERICA N · 2019 to 2020
$103k
Probing Inflammation and Reward Sensitivity in Alcohol Use DisorderF31AA028976 · NIAAA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BURNETTE, ELIZABETH · 2020 to 2022
$103k
Neuroimmune Treatment for AUD: Testing Moderators of Clinical Response and Mechanisms of ActionF31AA029295 · NIAAA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MEREDITH BROUSSARD, LINDSAY · 2022 to 2023
$59k
NIAAA NIH HHS F31 AA028976NIAAA NIH HHS F31 AA029295NIAAA NIH HHS F32 AA027699NIAAA NIH HHS K24 AA025704NIDA NIH HHS P50 DA005010NIDA NIH HHS T32 DA024635
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AlcoholismC-Reactive ProteinAlcohol DrinkingEthanolHumansInflammationC-Reactive ProteinEthanolAlcohol use disorderC-reactive proteinfMRIibudilastinflammation

Identifiers

PMID36282988
PMCPMC10840759
OpenAlexW4307220648

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.