ArticleProceedings of the National Academy of Sciences of the United States of America2022
With childhood hemispherectomy, one hemisphere can support-but is suboptimal for-word and face recognition.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Faces and Word Forms Can Coexist in the Right Ventro-occipital Temporal Cortex-Evidence from Left-Hemisphere Perinatal Stroke.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Growing up without a right hemisphere.Epilepsy & behavior reports · 2026Article
- Long-range axon branching: contributions to brain network plasticity and repair.Nature reviews. Neuroscience · 2026Review
- The Emergence of Topography and Hemispheric Lateralization in High-Level Vision.Quarterly journal of experimental psychology (2006) · 2026Review
- Lateralized excitation-inhibition rebalance correlates with motor recovery following hemispheric surgery.Brain communications · 2026Article
- Bidirectional and asymmetric smooth pursuit deficits in childhood hemispherectomy patients.Cortex; a journal devoted to the study of the nervous system and behavior · 2025Article
- Space- and object-based attention in patients with a single hemisphere following childhood resection.Scientific reports · 2025Article
- Cross-sectional and longitudinal changes in category selectivity in visual cortex following pediatric cortical resection.Communications biology · 2025Article
- Functional resilience of the neural visual recognition system post-pediatric occipitotemporal resection.iScience · 2024Article
- Hemispheric functional organization, as revealed by naturalistic neuroimaging, in pediatric epilepsy patients with cortical resections.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Functional Resilience of the Neural Visual Recognition System Post-Pediatric Occipitotemporal Resection.bioRxiv : the preprint server for biology · 2024Article
- Visual word processing engages a hierarchical, distributed, and bilateral cortical network.iScience · 2024Article
- Holistic processing and face expertise after pediatric resection of occipitotemporal cortex.Neuropsychologia · 2024Article
- Differential functional reorganization of ventral and dorsal visual pathways following childhood hemispherectomy.Developmental cognitive neuroscience · 2023Article
- Differential functional reorganization of ventral and dorsal visual pathways following childhood hemispherectomy.bioRxiv : the preprint server for biology · 2023Article
- An evidence-based critical review of the mind-brain identity theory.Frontiers in psychology · 2023Article
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4 authors.
Funding
Abstract
The right and left cerebral hemispheres are important for face and word recognition, respectively-a specialization that emerges over human development. The question is whether this bilateral distribution is necessary or whether a single hemisphere, be it left or right, can support both face and word recognition. Here, face and word recognition accuracy in patients (median age 16.7 y) with a single hemisphere following childhood hemispherectomy was compared against matched typical controls. In experiment 1, participants viewed stimuli in central vision. Across both face and word tasks, accuracy of both left and right hemispherectomy patients, while significantly lower than controls' accuracy, averaged above 80% and did not differ from each other. To compare patients' single hemisphere more directly to one hemisphere of controls, in experiment 2, participants viewed stimuli in one visual field to constrain initial processing chiefly to a single (contralateral) hemisphere. Whereas controls had higher word accuracy when words were presented to the right than to the left visual field, there was no field/hemispheric difference for faces. In contrast, left and right hemispherectomy patients, again, showed comparable performance to one another on both face and word recognition, albeit significantly lower than controls. Altogether, the findings indicate that a single developing hemisphere, either left or right, may be sufficiently plastic for comparable representation of faces and words. However, perhaps due to increased competition or "neural crowding," constraining cortical representations to one hemisphere may collectively hamper face and word recognition, relative to that observed in typical development with two hemispheres.
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