ArticleProceedings of the National Academy of Sciences of the United States of America2022
ADAR regulates APOL1 via A-to-I RNA editing by inhibition of MDA5 activation in a paradoxical biological circuit.
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In one paragraph
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Review
- Peripheral Transcriptomics in Acute and Long-Term Kidney Dysfunction in SARS-CoV-2 Infection.Kidney360 · 2025Article
- Advances in A-to-I RNA editing in cancer.Molecular cancer · 2024Review
- Inflammation primes the murine kidney for recovery by activating AZIN1 adenosine-to-inosine editing.The Journal of clinical investigation · 2024Article
- ADAR1 prevents ZBP1-dependent PANoptosis via A-to-I RNA editing in developmental sevoflurane neurotoxicity.Cell biology and toxicology · 2024Article
- A-to-I RNA co-editing predicts clinical outcomes and is associated with immune cells infiltration in hepatocellular carcinoma.Communications biology · 2024Article
- Inverted Alu repeats: friends or foes in the human transcriptome.Experimental & molecular medicine · 2024Review
- RNA editing enzymes: structure, biological functions and applications.Cell & bioscience · 2024Review
- Type I IFN in Glomerular Disease: Scarring beyond the STING.International journal of molecular sciences · 2024Review
- Inflammation primes the kidney for recovery by activating AZIN1 A-to-I editing.bioRxiv : the preprint server for biology · 2023Article
- ADAR regulates APOL1 via A-to-I RNA editing by inhibition of MDA5 activation in a paradoxical biological circuit.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
Corrections and comments
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Authors and funding
15 authors at 6 institutions in 3 countries.
Cristian V RiellaNephrology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215.
Michelle McNultyDivision of Pediatric Nephrology, Boston Children's Hospital, Boston, MA 02215.
Guilherme T RibasProfessional and Technological Education Sector, Federal University of Paraná, Curitiba 80060-000, Brazil.
Calum F TattersfieldNephrology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215.
Chandra Perez-GillNephrology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215.
Felix EichingerMichigan Kidney Translational Medical Core, University of Michigan, Ann Arbor, MI 48105-5714.
Jessica KellyNephrology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215.
Justin ChunDepartment of Medicine, University of Calgary, Calgary, AB T2N 1N4, Canada.ORCID 0000-0002-3820-7192
Balajikarthick SubramanianNephrology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215.
Dieval GuizeliniProfessional and Technological Education Sector, Federal University of Paraná, Curitiba 80060-000, Brazil.
Nephrotic Syndrome Study Network (NEPTUNE)
Seth L AlperNephrology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215.ORCID 0000-0002-6228-2512
Martin R PollakNephrology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215.
Matthew G SampsonDepartment of Medicinie, Harvard Medical School, Boston, MA 02115.
David J FriedmanNephrology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215.
Broad Institute · USBeth Israel Deaconess Medical Center · USMassachusetts General Hospital · USUniversidade Federal do Paraná · BRUniversity of Calgary · CAUniversity of Michigan · US
Funding
The Impact of COVID-19 on People Living with Rare Diseases and Their FamiliesU2CTR002818 · NCATS · CINCINNATI CHILDRENS HOSP MED CTR · PI Maurizio Macaluso · 2019 to 2026
$51.2MRegional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3MTraining Program in Clinical & Translationa Research in Human Glomerular DiseaseU54DK083912 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GIPSON, DEBBIE S · 2009 to 2023
$20.3MIntegrating large scale genomics and functional studies to accelerate FSGS/NS discoveryRC2DK122397 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI HILDEBRANDT, FRIEDHELM, POLLAK, MARTIN R. · 2020 to 2024
$7.4MAPOL1 variants: Understanding the basis of disparities in rates of kidney diseaseR01MD007092 · NIMHD · BETH ISRAEL DEACONESS MEDICAL CENTER · PI FRIEDMAN, DAVID J, POLLAK, MARTIN R. · 2012 to 2021
$4.3MWhole Genome Sequencing for Nephrotic Syndrome DiscoveryR01DK119380 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI Dongwon Lee, MATTHEW Gordon SAMPSON · 2019 to 2026
$3.7MAPOL1 - associated nephropathy from human-derived, intrarenal perspectiveR01DK108805 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MATTHEW Gordon SAMPSON, Simone Sanna-Cherchi · 2016 to 2026
$3.4MAPOL1 Nephropathy: Linking Genetics and MechanismsR01MD014726 · NIMHD · BETH ISRAEL DEACONESS MEDICAL CENTER · PI FRIEDMAN, DAVID J, POLLAK, MARTIN R. · 2020 to 2024
$2.4MNCATS NIH HHS U2C TR002818NIDDK NIH HHS P30 DK020572NIDDK NIH HHS R01 DK108805NIDDK NIH HHS R01 DK119380NIDDK NIH HHS RC2 DK122397NIDDK NIH HHS U54 DK083912NIMHD NIH HHS R01 MD007092NIMHD NIH HHS R01 MD014726
Abstract
PubMed holds no abstract for this paper.
Indexed as
Adenosine DeaminaseInterferon Type I3' Untranslated RegionsAdenosineAnimalsApolipoprotein L1HumansInosineInterferon-gammaInterferon-Induced Helicase, IFIH1MiceRNA, Double-StrandedRNA EditingRNA, Messenger3' Untranslated RegionsAdenosineAdenosine DeaminaseAPOL1 protein, humanApolipoprotein L1InosineInterferon-gammaInterferon-Induced Helicase, IFIH1Interferon Type IRNA, Double-StrandedRNA, MessengerADARAPOL1innate immunitykidney diseaseRNA editing
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LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.