ArticleScience signaling2022
Yap and Taz promote osteogenesis and prevent chondrogenesis in neural crest cells in vitro and in vivo.
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Article in Science signaling, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
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Who cites it
29 citing papers in PubMed, 44 citations in OpenAlex.
- Article
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- The Mechano-Genomic Frontier: Orchestrating Nuclear Deformation for Craniomaxillofacial Bone Regeneration.Journal of clinical medicine · 2026Review
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- An inducible mouse model of osteogenesis imperfecta type V reveals aberrant osteogenesis caused by Ifitm5 c.-14C>T mutation.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025Article
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- Augmented Bone Morphogenetic Protein Signaling During TMJ Development Alters Morphology in a Timepoint-Dependent Manner.International journal of molecular sciences · 2025Article
- The Hippo signalling pathway in bone homeostasis: Under the regulation of mechanics and aging.Cell proliferation · 2024Review
- Hyperbaric oxygen promotes bone regeneration by activating the mechanosensitive Piezo1 pathway in osteogenic progenitors.Journal of orthopaedic translation · 2024Article
- Mechanobiological Strategies to Enhance Ovine (Animals : an open access journal from MDPI · 2024Article
- YAP promotes the early development of temporomandibular joint bony ankylosis by regulating mesenchymal stem cell function.Scientific reports · 2024Article
- Nr4a1 enhances Wnt4 transcription to promote mesenchymal stem cell osteogenesis and alleviates inflammation-inhibited bone regeneration.Molecular therapy : the journal of the American Society of Gene Therapy · 2024Article
- IFT20 and WWTR1 govern bone homeostasis via synchronously regulating the expression and stability of TβRII in osteoblast lineage cells.Research square · 2024Article
Corrections and comments
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Authors and funding
17 authors at 4 institutions in 2 countries.
Xiaolei ZhaoDepartment of Pediatrics, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.ORCID 0000-0002-4697-3874
Li TangHunan Provincial Key Lab on Bioinformatics, School of Computer Science and Engineering, Central South University, Changsha, Hunan 410083, China.
Tram P LeDepartment of Pediatrics, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.ORCID 0000-0003-0260-0969
Bao H NguyenDepartment of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
Wen ChenDepartment of Pediatrics, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Mingjie ZhengDepartment of Pediatrics, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.ORCID 0000-0003-0735-3995
Hiroyuki YamaguchiDepartment of Pediatrics, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Brian DawsonDepartment of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
Shuangjie YouDepartment of Pediatrics, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Idaliz M Martinez-TraversoDepartment of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.ORCID 0000-0002-8127-8017
Shannon ErhardtDepartment of Pediatrics, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.ORCID 0000-0002-0189-0012
Jianxin WangHunan Provincial Key Lab on Bioinformatics, School of Computer Science and Engineering, Central South University, Changsha, Hunan 410083, China.
Min LiHunan Provincial Key Lab on Bioinformatics, School of Computer Science and Engineering, Central South University, Changsha, Hunan 410083, China.
James F MartinDepartment of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.ORCID 0000-0002-7842-9857
Brendan H LeeDepartment of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.ORCID 0000-0001-8573-4211
Yoshihiro KomatsuDepartment of Pediatrics, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Jun WangDepartment of Pediatrics, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.ORCID 0000-0001-6874-9331
Baylor College of Medicine · USThe University of Texas Health Science Center at Houston · USThe University of Texas MD Anderson Cancer Center · USCentral South University · CN
Funding
Pitx2 in atrial fibrillationR01HL118761 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI MARTIN, JAMES F · 2014 to 2025
$6.1MHippo and Wnt Signaling in Cardiac RegenerationR01HL127717 · NHLBI · TEXAS HEART INSTITUTE · PI MARTIN, JAMES F · 2016 to 2023
$4.4MGenetic dissection of Cardiac Conduction System homeostasis and RepairR01HL142704 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Jun Wang · 2020 to 2026
$3.0MMolecular Regulatory Mechanism of Cranial Neural Crest DevelopmentR01DE029014 · NIDCR · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI WANG, JUN · 2020 to 2024
$1.8MThe role of BMP signaling in craniofacial cartilage developmentR01DE025897 · NIDCR · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KOMATSU, YOSHIHIRO · 2017 to 2021
$1.8MA Hippo-Yap Pathway in Cranial Bone Development and RegenerationK01DE026561 · NIDCR · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI WANG, JUN · 2017 to 2021
$739kGenetic dissection of Cardiac Conduction System homeostasis and regenerationR56HL142704 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI WANG, JUN · 2018 to 2018
$396ka Yap/Taz mediated signaling crosstalk in cranial bone developmentR03DE025873 · NIDCR · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI WANG, JUN · 2017 to 2018
$313kNHLBI NIH HHS R01 HL118761NHLBI NIH HHS R01 HL127717NHLBI NIH HHS R01 HL142704NHLBI NIH HHS R56 HL142704NIDCR NIH HHS K01 DE026561NIDCR NIH HHS R01 DE025897NIDCR NIH HHS R01 DE029014NIDCR NIH HHS R03 DE025873
Abstract
Neural crest cells (NCCs) are multipotent stem cells that can differentiate into multiple cell types, including the osteoblasts and chondrocytes, and constitute most of the craniofacial skeleton. Here, we show through in vitro and in vivo studies that the transcriptional regulators Yap and Taz have redundant functions as key determinants of the specification and differentiation of NCCs into osteoblasts or chondrocytes. Primary and cultured NCCs deficient in
Indexed as
ChondrogenesisOsteogenesisAnimalsbeta CateninCell DifferentiationCore Binding Factor Alpha 1 SubunitMiceNeural CrestTCF Transcription FactorsTranscriptional Coactivator with PDZ-Binding Motif ProteinsYAP-Signaling Proteinsbeta CateninCore Binding Factor Alpha 1 SubunitTCF Transcription FactorsTranscriptional Coactivator with PDZ-Binding Motif ProteinsYAP-Signaling Proteins
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