Evidence map›Paper›PMID 36282507›Full record

ArticleAngewandte Chemie (International ed. in English)2022

The Single-Component Flavin Reductase/Flavin-Dependent Halogenase AetF is a Versatile Catalyst for Selective Bromination and Iodination of Arenes and Olefins.

Yuhua Jiang, Harrison M Snodgrass, Yasmine S Zubi, Caitlin V Roof, Yanfei Guan, Dibyendu Mondal, Nicholas H Honeycutt, Johnny W Lee, Russell D Lewis, Carlos A Martinez and 1 more

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Peptidic Tryptophan Halogenation by a Promiscuous Flavin-Dependent Enzyme.Angewandte Chemie (International ed. in English) · 2025
    Article
  5. Article
  6. Article
  7. Mining for Halogenated Metabolites ofJournal of natural products · 2025
    Article
  8. Recent Advances in Iodine-Mediated Radical Reactions.Advanced synthesis & catalysis · 2025
    Article
  9. Article
  10. Unlocking the catalytic precision of ligand-controlled enzymatic halogenation.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  11. Review
  12. Article
  13. Article
  14. Enzymatic Halogenation of Terminal Alkynes.Journal of the American Chemical Society · 2023
    Article
  15. Review
  16. Review
  17. Article
  18. Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yuhua JiangDepartment of Chemistry, Indiana University, Bloomington, IN 47405, USA.
Harrison M SnodgrassDepartment of Chemistry, Indiana University, Bloomington, IN 47405, USA.
Yasmine S ZubiDepartment of Chemistry, Indiana University, Bloomington, IN 47405, USA.
Caitlin V RoofDepartment of Chemistry, Indiana University, Bloomington, IN 47405, USA.
Yanfei GuanChemical Research & Development, Pfizer Worldwide Research & Development, Groton, Connecticut 06340, USA.
Dibyendu MondalDepartment of Chemistry, Indiana University, Bloomington, IN 47405, USA.
Nicholas H HoneycuttDepartment of Chemistry, Indiana University, Bloomington, IN 47405, USA.
Johnny W LeeChemical Research & Development, Pfizer Worldwide Research & Development, Groton, Connecticut 06340, USA.
Russell D LewisChemical Research & Development, Pfizer Worldwide Research & Development, Groton, Connecticut 06340, USA.
Carlos A MartinezChemical Research & Development, Pfizer Worldwide Research & Development, Groton, Connecticut 06340, USA.
Jared C LewisDepartment of Chemistry, Indiana University, Bloomington, IN 47405, USA.ORCID 0000-0003-2800-8330

Funding

Directed Evolution of Halogenases For Small Molecule FunctionalizationR01GM115665 · NIGMS · UNIVERSITY OF CHICAGO · PI LEWIS, JARED C · 2015 to 2022
$2.5M
Graduate Training Program in Quantitative and Chemical Biology at Indiana University BloomingtonT32GM131994 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI JARED C LEWIS · 2019 to 2026
$2.4M
NIGMS NIH HHS R01 GM115665NIGMS NIH HHS T32 GM131994
6 · The paper itself

Abstract

Flavin-dependent halogenases (FDHs) natively catalyze selective halogenation of electron rich aromatic and enolate groups. Nearly all FDHs reported to date require a separate flavin reductase to supply them with FADH

Indexed as

AlkenesOxidoreductasesBiocatalysisFlavinsHalogenationAlkenesFlavinsOxidoreductasesAtroposelectivityC−H FunctionalizationFlavin Dependent HalogenaseHalocyclizationIodinase

Identifiers

PMID36282507
PMCPMC9772203

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.