ArticleSpine deformity2023
A high prevalence of Cutibacterium acnes infections in scoliosis revision surgery, a diagnostic and therapeutic dilemma.
Article in Spine deformity, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Long-term patient-reported outcomes and mechanical complications following spinal fusion in patients with surgical site infection managed with retained instrumentation versus non-infected patients: a systematic review and meta-analysis.Journal of spine surgery (Hong Kong) · 2026Article
- Limited Diagnostic Utility of Postoperative C-Reactive Protein for Early Detection of Surgical Site Infections Following Posterior Scoliosis Correction Surgery.Journal of clinical medicine · 2025Article
- Value ofWorld journal of nuclear medicine · 2024Article
- Defeating the Hidden Foe: Antibiotic Therapy and Clinical Outcomes ofOpen forum infectious diseases · 2023Article
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7 authors.
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Abstract
purposeTo investigate if serum inflammatory markers or nuclear imaging can accurately diagnose a chronic spinal instrumentation infection (SII) prior to surgery.
methodsAll patients who underwent revision of spinal instrumentation after a scoliosis correction between 2017 and 2019, were retrospectively evaluated. The diagnostic accuracy of serum C-reactive protein (CRP) and Erythrocyte Sedimentation Rate (ESR),
results30 patients were included. The indication for revision surgery was pseudoarthrosis in the majority of patients (n = 15). 22 patients (73%) were diagnosed with SII. In all infected cases, Cutibacterium acnes was isolated, including 5 cases with a polymicrobial infection. The majority of patients had low inflammatory parameters preoperatively. For CRP > 10.0 mg/L, the sensitivity was 9.1% and specificity 100%; for ESR > 30 mm/h, the sensitivity was 9.1% and specificity 100%. The diagnostic accuracy for nuclear imaging was 64% for the FDG-PET/CT and 67% for the TPBS to diagnose infection.
conclusionsThe prevalence of SII in patients undergoing revision spinal surgery is high, with Cutibacterium acnes as the main pathogen. No diagnostic tests could be identified that could accurately diagnose or exclude SII prior to surgery. Future studies should aim to find more sensitive diagnostic modalities to detect low-grade inflammation.
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