Evidence map›Paper›PMID 36282407›Full record

Trial reportMedical & biological engineering & computing2022

Impact of repetitive transcranial magnetic stimulation on the directed connectivity of autism EEG signals: a pilot study.

Jiannan Kang, Xiaoli Li, Manuel F Casanova, Estate M Sokhadze, Xinling Geng

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Medical & biological engineering & computing, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Jiannan KangCollege of Electronic & Information Engineering, Hebei University, Baoding, China.
Xiaoli LiState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
Manuel F CasanovaDepartment of Biomedical Sciences, University of South Carolina School of Medicine Greenville Campus, Prisma Health System, Greenville, SC, USA.
Estate M SokhadzeDepartment of Biomedical Sciences, University of South Carolina School of Medicine Greenville Campus, Prisma Health System, Greenville, SC, USA.
Xinling GengSchool of Biomedical Engineering, Capital Medical University, Beijing, China. gengxl@ccmu.edu.cn.
University of South Carolina · USBeijing Normal University · CNCapital Medical University · CNHebei University · CN

Funding

Young Scientists Fund 62001153
6 · The paper itself

Abstract

To compare the differences in directed connectivity between typically developing (TD) and autism spectrum disorder (ASD) children and identify the potential effects of repetitive transcranial magnetic stimulation (rTMS) on brain connectivity and behavior of children with ASD; 26 TD children (18 males/8 females; the average age was 6.34 ± 0.45) and 30 ASD children (21 males/9 females; the average age was 6.42 ± 0.17) participated in the experiment. ASD children were divided randomly into an experimental group and a control group. The experimental group received 18 rTMS sessions (twice a week for nine weeks), whereas the control group received the same procedures with sham stimulation. Directed transfer function (DTF) was used to calculate the effective connectivity as a way of investigating differences between ASD and TD children while simultaneously evaluating the effectiveness of rTMS for ASD. The results illustrate that the DTF of TD children in the frontal lobe (Fp1, Fp2, F7, F8) and temporal lobe (T7, T8) is higher than that of ASD children in all frequency bands; however, the DTF of ASD children is higher than TD in the midline (Fz, Cz), central lobe (C3, C4), and parietal lobe (P3, P4). In the experimental group of ASD children, the effective connectivity decreased from O1 to T7 and from P7 to Fp1 in the alpha band and from Pz to T8 in the gamma band after stimulation. Significant changes in Autism Behavior Checklist (ABC) scores were also found in social behaviors. Effective connectivity derived from DTF distinguishes ASD from TD children. rTMS provides changes in connectivity and behavior, suggesting its potential use as a viable treatment option for ASD individuals.

Indexed as

Autism Spectrum DisorderAutistic DisorderBrainChildChild, PreschoolElectroencephalographyFemaleHumansMalePilot ProjectsTranscranial Magnetic StimulationAutism spectrum disorder (ASD)Directed transfer function (DTF)Effective connectivityRepetitive transcranial magnetic stimulation (rTMS)

Identifiers

PMID36282407
OpenAlexW4307234215

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.