Evidence map›Paper›PMID 36282402›Full record

ArticleWiener medizinische Wochenschrift (1946)2023

Significance of reduced renal function in patients with chronic myelomonocytic leukemia.

Julia Heschl, Klaus Geissler

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Wiener medizinische Wochenschrift (1946), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Clonal monocytosis of renal significance.Kidney international · 2024
    Review
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Julia HeschlMedical School, Sigmund Freud University, Vienna, Austria.
Klaus GeisslerMedical School, Sigmund Freud University, Vienna, Austria. klaus.geissler@med.sfu.ac.at.ORCID http://orcid.org/0000-0003-1921-7034
Sigmund Freud Privatuniversität Wien · AT

Funding

Gesellschaft zur Erforschung der Biologie und Therapie von Tumorkrankheiten ABCMML-112015
6 · The paper itself

Abstract

In a retrospective study, we analyzed the prevalence of increased creatinine levels in 166 patients with chronic myelomonocytic leukemia (CMML), their potential prognostic impact, and potential correlations with laboratory and molecular features. Increased creatinine values (> 1.1 mg/dl) were found in 71 of 166 (43%) patients. The median survival of patients with increased creatinine values was significantly shorter than in patients without impairment of renal function (20 vs. 52 months, p < 0.001). Patients with increased creatinine values were older, were more often male, had higher leukocyte counts, higher monocyte counts, and higher lactatdehydrogenase (LDH) values. There was a trend toward a higher prevalence of CBL and ASXL1 mutations in patients with renal impairment. Our findings show a high prevalence of renal abnormalities in patients with CMML. Increased creatinine values were identified as a new prognostic marker. These findings may be important for the individualized management of this heterogenous group of patients.

Indexed as

Leukemia, Myelomonocytic, ChronicCreatinineHumansKidneyMaleMutationPrognosisRetrospective StudiesCreatinineCMMLComorbidityCreatinine levelRenal functionSurvival

Identifiers

PMID36282402
PMCPMC9876845
OpenAlexW4307229972

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.