ArticleApplied microbiology and biotechnology2022
Production of propionate using metabolically engineered strains of Clostridium saccharoperbutylacetonicum.
Article in Applied microbiology and biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Who cites it
6 citing papers in PubMed, 19 citations in OpenAlex.
- Recent advances in microbial production of odd-chain fatty acids.World journal of microbiology & biotechnology · 2026Review
- Enhancement of lactate fraction in poly(lactate-co-3-hydroxybutyrate) biosynthesized by metabolically engineered E. coli.Bioresources and bioprocessing · 2024Article
- Propionate production by Bacteroidia gut bacteria and its dependence on substrate concentrations differs among species.Biotechnology for biofuels and bioproducts · 2024Article
- The oxidoreductase activity of Rnf balances redox cofactors during fermentation of glucose to propionate in Prevotella.Scientific reports · 2023Article
- Heterologous 1,3-Propanediol Production Using Different RecombinantMicroorganisms · 2023Article
- New Insights into the Physiology of the Propionate ProducersMicroorganisms · 2023Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
The carboxylic acid propionate is a valuable platform chemical with applications in various fields. The biological production of this acid has become of great interest as it can be considered a sustainable alternative to petrochemical synthesis. In this work, Clostridium saccharoperbutylacetonicum was metabolically engineered to produce propionate via the acrylate pathway. In total, the established synthetic pathway comprised eight genes encoding the enzymes catalyzing the conversion of pyruvate to propionate. These included the propionate CoA-transferase, the lactoyl-CoA dehydratase, and the acryloyl-CoA reductase from Anaerotignum neopropionicum as well as a D-lactate dehydrogenase from Leuconostoc mesenteroides subsp. mesenteroides. Due to difficulties in assembling all genes on one plasmid under the control of standard promoters, the P
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Registered trials
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