Evidence map›Paper›PMID 36281968›Full record

ArticleActa psychiatrica Scandinavica2023

The effect of depressive symptoms on disability-free survival in healthy older adults: A prospective cohort study.

Greg Roebuck, Mojtaba Lotfaliany, Bruno Agustini, Malcolm Forbes, Mohammadreza Mohebbi, John McNeil, Robyn L Woods, Christopher M Reid, Mark R Nelson, Raj C Shah and 7 more

Full text read
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In one paragraph

Article in Acta psychiatrica Scandinavica, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. [Prevention of depression in old age: individual and societal relevance].Zeitschrift fur Gerontologie und Geriatrie · 2024
    Article
  6. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Greg RoebuckThe Institute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine, Deakin University, and Barwon Health, Geelong, Victoria, Australia.
Mojtaba LotfalianyThe Institute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine, Deakin University, and Barwon Health, Geelong, Victoria, Australia.
Bruno AgustiniThe Institute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine, Deakin University, and Barwon Health, Geelong, Victoria, Australia.
Malcolm ForbesThe Institute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine, Deakin University, and Barwon Health, Geelong, Victoria, Australia.
Mohammadreza MohebbiBiostatistics Unit, Deakin University, Geelong, Victoria, Australia.ORCID 0000-0001-9713-7211
John McNeilSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Robyn L WoodsSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Christopher M ReidSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Mark R NelsonMenzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.
Raj C ShahDepartment of Family Medicine and Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
Joanne RyanSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Anne B NewmanSchool of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Alice OwenSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Rosanne Freak-PoliSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Nigel StocksDiscipline of General Practice, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, South Australia, Australia.
Michael BerkThe Institute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine, Deakin University, and Barwon Health, Geelong, Victoria, Australia.ORCID 0000-0002-5554-6946
ASPREE Investigator Group

Funding

ASPirin in Reducing Events in the ElderlyU01AG029824 · NIA · HENNEPIN HEALTHCARE RESEARCH INSTITUTE · PI MCNEIL, JOHN JAMES, MURRAY, ANNE M · 2009 to 2018
$64.6M
Main Administrative CoreU19AG062682 · NIA · HENNEPIN HEALTHCARE RESEARCH INSTITUTE · PI CHAN, ANDREW T, MCNEIL, JOHN JAMES · 2019 to 2023
$42.9M
NIA NIH HHS U01 AG029824NIA NIH HHS U19 AG062682
6 · The paper itself

Abstract

backgroundGerontology and ageing research are increasingly focussing on healthy life span (healthspan), the period of life lived free of serious disease and disability. Late-life depression (LLD) is believed to impact adversely on physical health. However, no studies have examined its effect on healthspan. This study investigated the effect of LLD and subthreshold depression on disability-free survival, a widely accepted measure of healthspan.

methodsThis prospective cohort study used data from the ASPirin in Reducing Events in the Elderly study. Participants were aged ≥70 years (or ≥65 years for African-American and Hispanic participants) and free of dementia, physical disability and cardiovascular disease. Depressive symptoms were measured using the 10-item Centre for Epidemiological Studies Depression Scale (CES-D-10). LLD and subthreshold depression were defined as CES-D-10 scores ≥8 and 3-7, respectively. Disability-free survival was defined as survival free of dementia and persistent physical disability.

resultsA total of 19,110 participants were followed up for a maximum of 7.3 years. In female participants, LLD was associated with lower disability-free survival adjusting for sociodemographic and lifestyle factors, medical comorbidities, polypharmacy, physical function and antidepressant use (HR, 1.50; 95% CI, 1.23-1.82). In male participants, LLD was associated with lower disability-free survival adjusting for sociodemographic and lifestyle factors (HR, 1.30; 95% CI, 1.03-1.64). Subthreshold depression was also associated with lower disability-free survival in both sexes.

conclusionsLLD may be a common and important risk factor for shortened healthspan.

Indexed as

DementiaPersons with DisabilitiesAgedAntidepressive AgentsDepressionFemaleHumansMaleProspective StudiesAntidepressive Agentsageingdisability-free survivalhealthspanlate-life depressionpsychiatry

Identifiers

PMID36281968
PMCPMC10026010

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read32
table measurements read25
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.