Evidence map›Paper›PMID 36281763›Full record

Trial reportHypertension (Dallas, Tex. : 1979)2022

Comparing Pharmacist-Led Telehealth Care and Clinic-Based Care for Uncontrolled High Blood Pressure: The Hyperlink 3 Pragmatic Cluster-Randomized Trial.

Karen L Margolis, Anna R Bergdall, A Lauren Crain, Meghan M JaKa, Jeffrey P Anderson, Leif I Solberg, JoAnn Sperl-Hillen, MarySue Beran, Beverly B Green, Patricia Haugen and 13 more

3 registry-linked trialsOpen access · bronzeAbstract readRandomized Controlled TrialPragmatic Clinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Hypertension (Dallas, Tex. : 1979), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 32 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 8 pooled it
9.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02996565 nacompletednot on this map

Pragmatic Trial Comparing Telehealth Care and Optimized Clinic-Based Care for Uncontrolled High Blood Pressure

TypeinterventionalSponsorHealthPartners InstituteRan2017 to 2021Enrolled3,071ConditionsHypertensionArmsBest Practice Clinic-Based Care, Telehealth Care
NCT07232017 recruitingnot on this mapstarted 2026, after this paper: background citation

Implementation of Intensive Hypertension Management Approaches: Cleveland Clinic

TypeobservationalSponsorAnita Misra-HebertRan2026 to 2029Enrolled1,520ConditionsHypertension (HTN)ArmsIN-HOME BP
NCT07397260 naenrolling by invitationnot on this mapstarted 2026, after this paper: background citation

Effects of Manually Recorded or Automatically Transmitted Home Blood Pressures With or Without Automated Patient Feedback on Hypertension Care

TypeinterventionalSponsorNorthwestern UniversityRan2026 to 2028Enrolled1,304ConditionsHypertension (HTN)ArmsSelf report of home measured blood pressure via patient EHR portal, Automated feedback about home blood pressure results, Automated Transmission of Remotely Measured Blood Pressure
3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 8 syntheses or guidelines pooled it, 58 citations in OpenAlex.

  1. Guideline
  2. Pooled it
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  4. Impact of patient care teams on blood pressure control in patients with hypertension: a systematic review and meta-analysis.Hypertension research : official journal of the Japanese Society of Hypertension · 2025
    Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Trial
  10. Trial
  11. Trial
  12. Review
  13. Article
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  15. Article
  16. Article
  17. Remote Blood Pressure Monitoring: A Comprehensive Review.American journal of hypertension · 2026
    Review
  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 3 institutions in 1 country.

Karen L MargolisHealthPartners Institute, Minneapolis, MN (K.L.M., A.R.B., A.L.C., M.M.J., J.P.A., L.I.S., J.S.-H., M.B., P.H., C.K.N., A.J.K., R.S., D.A., N.K.T., P.A.P., Z.J.M., T.E.K., J.Y.Z., P.J.O.).ORCID 0000-0003-1862-7402
Anna R BergdallHealthPartners Institute, Minneapolis, MN (K.L.M., A.R.B., A.L.C., M.M.J., J.P.A., L.I.S., J.S.-H., M.B., P.H., C.K.N., A.J.K., R.S., D.A., N.K.T., P.A.P., Z.J.M., T.E.K., J.Y.Z., P.J.O.).
A Lauren CrainHealthPartners Institute, Minneapolis, MN (K.L.M., A.R.B., A.L.C., M.M.J., J.P.A., L.I.S., J.S.-H., M.B., P.H., C.K.N., A.J.K., R.S., D.A., N.K.T., P.A.P., Z.J.M., T.E.K., J.Y.Z., P.J.O.).
Meghan M JaKaHealthPartners Institute, Minneapolis, MN (K.L.M., A.R.B., A.L.C., M.M.J., J.P.A., L.I.S., J.S.-H., M.B., P.H., C.K.N., A.J.K., R.S., D.A., N.K.T., P.A.P., Z.J.M., T.E.K., J.Y.Z., P.J.O.).ORCID 0000-0001-5744-7215
Jeffrey P AndersonHealthPartners Institute, Minneapolis, MN (K.L.M., A.R.B., A.L.C., M.M.J., J.P.A., L.I.S., J.S.-H., M.B., P.H., C.K.N., A.J.K., R.S., D.A., N.K.T., P.A.P., Z.J.M., T.E.K., J.Y.Z., P.J.O.).ORCID 0000-0003-4048-3919
Leif I SolbergHealthPartners Institute, Minneapolis, MN (K.L.M., A.R.B., A.L.C., M.M.J., J.P.A., L.I.S., J.S.-H., M.B., P.H., C.K.N., A.J.K., R.S., D.A., N.K.T., P.A.P., Z.J.M., T.E.K., J.Y.Z., P.J.O.).
JoAnn Sperl-HillenHealthPartners Institute, Minneapolis, MN (K.L.M., A.R.B., A.L.C., M.M.J., J.P.A., L.I.S., J.S.-H., M.B., P.H., C.K.N., A.J.K., R.S., D.A., N.K.T., P.A.P., Z.J.M., T.E.K., J.Y.Z., P.J.O.).
MarySue BeranHealthPartners Institute, Minneapolis, MN (K.L.M., A.R.B., A.L.C., M.M.J., J.P.A., L.I.S., J.S.-H., M.B., P.H., C.K.N., A.J.K., R.S., D.A., N.K.T., P.A.P., Z.J.M., T.E.K., J.Y.Z., P.J.O.).
Beverly B GreenKaiser Permanente Washington Health Research Institute, Seattle (B.B.G.).ORCID 0000-0003-3040-3436
Patricia HaugenHealthPartners Institute, Minneapolis, MN (K.L.M., A.R.B., A.L.C., M.M.J., J.P.A., L.I.S., J.S.-H., M.B., P.H., C.K.N., A.J.K., R.S., D.A., N.K.T., P.A.P., Z.J.M., T.E.K., J.Y.Z., P.J.O.).
Christine K NortonHealthPartners Institute, Minneapolis, MN (K.L.M., A.R.B., A.L.C., M.M.J., J.P.A., L.I.S., J.S.-H., M.B., P.H., C.K.N., A.J.K., R.S., D.A., N.K.T., P.A.P., Z.J.M., T.E.K., J.Y.Z., P.J.O.).
Amy J KodetHealthPartners Institute, Minneapolis, MN (K.L.M., A.R.B., A.L.C., M.M.J., J.P.A., L.I.S., J.S.-H., M.B., P.H., C.K.N., A.J.K., R.S., D.A., N.K.T., P.A.P., Z.J.M., T.E.K., J.Y.Z., P.J.O.).ORCID 0000-0002-8039-5422
Rashmi SharmaHealthPartners Institute, Minneapolis, MN (K.L.M., A.R.B., A.L.C., M.M.J., J.P.A., L.I.S., J.S.-H., M.B., P.H., C.K.N., A.J.K., R.S., D.A., N.K.T., P.A.P., Z.J.M., T.E.K., J.Y.Z., P.J.O.).
Deepika AppanaHealthPartners Institute, Minneapolis, MN (K.L.M., A.R.B., A.L.C., M.M.J., J.P.A., L.I.S., J.S.-H., M.B., P.H., C.K.N., A.J.K., R.S., D.A., N.K.T., P.A.P., Z.J.M., T.E.K., J.Y.Z., P.J.O.).
Nicole K TrowerHealthPartners Institute, Minneapolis, MN (K.L.M., A.R.B., A.L.C., M.M.J., J.P.A., L.I.S., J.S.-H., M.B., P.H., C.K.N., A.J.K., R.S., D.A., N.K.T., P.A.P., Z.J.M., T.E.K., J.Y.Z., P.J.O.).
Pamala A PawloskiHealthPartners Institute, Minneapolis, MN (K.L.M., A.R.B., A.L.C., M.M.J., J.P.A., L.I.S., J.S.-H., M.B., P.H., C.K.N., A.J.K., R.S., D.A., N.K.T., P.A.P., Z.J.M., T.E.K., J.Y.Z., P.J.O.).ORCID 0000-0002-1005-5764
Daniel J RehrauerHealthPartners, Minneapolis, MN (D.J.R., M.L.S., R.A.W.).
Maria L SimmonsHealthPartners, Minneapolis, MN (D.J.R., M.L.S., R.A.W.).
Zeke J McKinneyHealthPartners Institute, Minneapolis, MN (K.L.M., A.R.B., A.L.C., M.M.J., J.P.A., L.I.S., J.S.-H., M.B., P.H., C.K.N., A.J.K., R.S., D.A., N.K.T., P.A.P., Z.J.M., T.E.K., J.Y.Z., P.J.O.).ORCID 0000-0002-1858-8426
Thomas E KottkeHealthPartners Institute, Minneapolis, MN (K.L.M., A.R.B., A.L.C., M.M.J., J.P.A., L.I.S., J.S.-H., M.B., P.H., C.K.N., A.J.K., R.S., D.A., N.K.T., P.A.P., Z.J.M., T.E.K., J.Y.Z., P.J.O.).
Jeanette Y ZiegenfussHealthPartners Institute, Minneapolis, MN (K.L.M., A.R.B., A.L.C., M.M.J., J.P.A., L.I.S., J.S.-H., M.B., P.H., C.K.N., A.J.K., R.S., D.A., N.K.T., P.A.P., Z.J.M., T.E.K., J.Y.Z., P.J.O.).
Rae Ann WilliamsHealthPartners, Minneapolis, MN (D.J.R., M.L.S., R.A.W.).
Patrick J O'ConnorHealthPartners Institute, Minneapolis, MN (K.L.M., A.R.B., A.L.C., M.M.J., J.P.A., L.I.S., J.S.-H., M.B., P.H., C.K.N., A.J.K., R.S., D.A., N.K.T., P.A.P., Z.J.M., T.E.K., J.Y.Z., P.J.O.).ORCID 0000-0002-2324-6228
Anna Needs Neuroblastoma Answers · USHealthPartners · USKaiser Permanente Washington Health Research Institute · US

Funding

Patient-Centered Outcomes Research Institute IHS-1507-31146
6 · The paper itself

Abstract

backgroundA team approach is one of the most effective ways to lower blood pressure (BP) in uncontrolled hypertension, but different models for organizing team-based care have not been compared directly.

methodsA pragmatic, cluster-randomized trial compared 2 interventions in adult patients with moderately severe hypertension (BP≥150/95 mm Hg): (1) clinic-based care using best practices and face-to-face visits with physicians and medical assistants; and (2) telehealth care using best practices and adding home BP telemonitoring with home-based care coordinated by a clinical pharmacist or nurse practitioner. The primary outcome was change in systolic BP over 12 months. Secondary outcomes were change in patient-reported outcomes over 6 months.

resultsParticipants (N=3071 in 21 primary care clinics) were on average 60 years old, 47% male, and 19% Black. Protocol-specified follow-up within 6 weeks was 32% in clinic-based care and 27% in telehealth care. BP decreased significantly during 12 months of follow-up in both groups, from 157/92 to 139/82 mm Hg in clinic-based care patients (adjusted mean difference -18/-10 mm Hg) and 157/91 to 139/81 mm Hg in telehealth care patients (adjusted mean difference -19/-10 mm Hg), with no significant difference in systolic BP change between groups (-0.8 mm Hg [95% CI, -2.84 to 1.32]). Telehealth care patients were significantly more likely than clinic-based care patients to report frequent home BP measurement, rate their BP care highly, and report that BP care visits were convenient.

conclusionsTelehealth care that includes extended team care is an effective and safe alternative to clinic-based care for improving patient-centered care for hypertension. REGISTRATION: URL: https://www. CLINICALTRIALS: gov; Unique identifier: NCT02996565.

Indexed as

HypertensionTelemedicineAdultAntihypertensive AgentsBlood PressureBlood Pressure DeterminationFemaleHumansMaleMiddle AgedPharmacistsAntihypertensive Agentsblood pressurehypertensionnurse practitionerspatient-reported outcomespharmacistsphysicianstelemedicine

Identifiers

PMID36281763
PMCPMC9649877
OpenAlexW4307198307

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.