Evidence map›Paper›PMID 36281709›Full record

ReviewBasic & clinical pharmacology & toxicology2023

Deaths caused by medication in persons not using illicit narcotic drugs: An autopsy study from Western Denmark.

Charlotte U Andersen, Hafsa Ahmed, Mathias Raedkjaer, Jørgen B Hasselstrøm, Maiken K Larsen

Open access · hybridAbstract readReview
In one paragraph

Review in Basic & clinical pharmacology & toxicology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Charlotte U AndersenDepartment of Forensic Medicine, Aarhus University, Aarhus, Denmark.ORCID https://orcid.org/0000-0003-0543-6519
Hafsa AhmedDepartment of Forensic Medicine, Aarhus University, Aarhus, Denmark.
Mathias RaedkjaerDepartment of Forensic Medicine, Aarhus University, Aarhus, Denmark.
Jørgen B HasselstrømDepartment of Forensic Medicine, Aarhus University, Aarhus, Denmark.
Maiken K LarsenDepartment of Forensic Medicine, Aarhus University, Aarhus, Denmark.
Aarhus University · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Information regarding deaths caused by poisoning or adverse effects of medication in Danish persons not using illicit narcotic drugs (PNUIDs) is sparse. To characterize aetiology, demographics, and death scene, we reviewed all legal autopsies performed at Aarhus University from 2017 to 2019 and isolated 96 deaths caused by medications in PNUIDs. Suicides caused by medication overdose accounted for 38%. Opioids and psychotropic medications were the main cause of death in 48% and 35% of the 96 cases, respectively. Morphine, tramadol, and quetiapine were the most commonly involved individual medications. A single medication caused death in 50% of cases, and multiple substances were involved in 50%. The median total number [interquartile range] of detected medications was 5 [4-6], with a higher number in females (5 [4-7]) than males (4 [2-5]), p = 0.009. Median age was 51 [42.5-61.5] years, and 57% were female. Scene of death most frequently involved a body on a bed or couch in the decedent's own home (72%). In conclusion, opioids and psychotropic medications dominated by morphine, tramadol and quetiapine most frequently caused medication-related deaths in PNUIDs. Monitoring this type of death may yield important knowledge to direct prophylactic initiatives regarding medication use and prescription.

Indexed as

Drug OverdoseIllicit DrugsSuicideTramadolAnalgesics, OpioidAutopsyDenmarkFemaleHumansMaleMiddle AgedMorphine DerivativesNarcoticsPsychotropic DrugsQuetiapine FumarateAnalgesics, OpioidIllicit DrugsMorphine DerivativesNarcoticsPsychotropic DrugsQuetiapine FumarateTramadolclinical toxicologyforensic toxicologymedicationopioidspsychiatrypsychopharmacology

Identifiers

PMID36281709
PMCPMC10092188
OpenAlexW4307233303

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.