ArticleAnnals of laboratory medicine2023
Performance Comparison Between Fourier-Transform Infrared Spectroscopy-based IR Biotyper and Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry for Strain Diversity.
Article in Annals of laboratory medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Performance of the IR Biotyper, Nanopore, and Illumina sequencing to discriminateMicrobiology spectrum · 2026Article
- FT-IR Spectroscopy to Discriminate Old from NewInternational journal of molecular sciences · 2026Article
- Multispectral Infrared Colony Phenotyping for High-Throughput Microbiological Control of Waters.Journal of biophotonics · 2026Article
- Discrimination of Bacteria Belonging toMicroorganisms · 2026Article
- Rapid Typing of Extended-Spectrum β-Lactamase (ESBL)- and Metallo-β-Lactamase (MBL)-Producing Enterobacterales Using Fourier Transform Infrared (FT-IR) Spectroscopy.MicrobiologyOpen · 2026Article
- Performance of FTIR-Based IR Biotyper for Identification and Strain Discrimination ofMycobiology · 2026Article
- Use of a national repository of Fourier-transform infrared spectroscopy spectra enables fast detection of silent outbreaks and prevention of spread of new antibiotic-resistant sequence types.Antimicrobial resistance and infection control · 2025Article
- Microbial Identification Through Multispectral Infrared Imaging of Colonies: A New Type of Morpho-Spectral Fingerprinting.Microbial biotechnology · 2025Article
- A Comprehensive Methodology for Microbial Strain Typing Using Fourier-Transform Infrared Spectroscopy.Methods and protocols · 2024Article
- Comparative analysis of IR-Biotyper, MLST, cgMLST, and WGS for clustering of vancomycin-resistantMicrobiology spectrum · 2024Article
- Development and validation of a quick, automated, and reproducible ATR FT-IR spectroscopy machine-learning model forJournal of clinical microbiology · 2024Article
- Application of Fourier Transform Infrared Spectroscopy to Discriminate Two Closely Related Bacterial Species:Microorganisms · 2024Article
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Authors and funding
9 authors.
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Abstract
Background: Development of an accessible method to routinely evaluate the clonality of strains is needed in microbiology laboratories. We compared the discriminatory power of the Fourier-transform infrared (FTIR) spectroscopy-based IR Biotyper (Bruker Daltonics GmbH, Bremen, Germany) to matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS), using whole-genome sequencing (WGS) as the reference method. Methods: Eighty-three extended-spectrum β-lactamase-producing Results: The SDI (95% confidence interval) was 0.969 (0.952-0.985) for WGS, 0.865 (0.807-0.924) for MALDI-TOF MS, and 0.974 (0.965-0.983) for IR Biotyper. Compared with WGS, IR Biotyper showed compatible diversity, whereas MALDI-TOF MS did not. The concordance and aRI improved from 66.3% to 84.3% and from 0.173 to 0.538, respectively, for IR Biotyper versus MALDI-TOF MS with WGS as the reference method. IR Biotyper showed substantially improved performance in strain typing compared with MALDI-TOF MS. Conclusions: IR Biotyper is useful for diversity analysis with improved discriminatory power over MALDI-TOF MS in comparison with WGS as a reference method. IR Biotyper is an accessible method to evaluate the clonality of strains and could be applied in epidemiological analysis during an outbreak of a health care facility, as well as for research on the transmission of resistant bacteria in community settings.
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